An observational study in Headache, Pain, Head and Muscle Tenderness, sponsored by Danish Headache Center. Completed at 1 site in Denmark. Open to male participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2021-03-25.
Sponsored by Danish Headache Center · Observational
Headaches are extremely common illnesses with a combined lifetime prevalence of 90-99% in Europe. Despite this high prevalence, there are persons who have never, in their whole life, encountered a headache.
The aim of the study is to identify factors that protect against headache by studying pain perception, muscle tenderness and pain tolerance in people who never have had a headache (headache resistant) versus non-resistant controls.
The investigators hope to contribute with novelty to the current understanding of headache pathophysiology and development of more efficient treatment of headache.
The investigator examining:
Quantitative sensory testing (cold pain threshold and heat pain threshold), Muscle tenderness (total tenderness score) and cold pressor test (time in the water and pain rating). All tests are performed the same day, by one investigator who are blinded to the grouping of the participants.
282 studies on the registry are indexed under Myalgia; 43 are open to participants now.
This study's enrollment of 100 is below the median of 154 across 35 observational studies indexed under Myalgia.
Browse Myalgia studies →Danish Headache Center is the lead sponsor of 125 studies on the registry; 15 are open to participants now.
Counted across the registry records on this site, refreshed daily.
50 Headache resistant and 50 non-resistant male participants from the Danish Blood Donor Study.
Exclusion Criteria:
Male participants who have never had a headache.
Male participants who have experienced headache. Age matched.
Quantitative Sensory Test: Cold Pain Threshold
Difference in Cold Pain Threshold (celcius) between cases and controls.
Time frame: 3 hours
Quantitative Sensory Test: Heat Pain Threshold
Difference in Heat Pain Threshold (celcius) between cases and controls.
Time frame: 3 hours.
Pericranial Muscle Tenderness: Total Tenderness Scores
Difference in Total Tenderness Score between cases and controls. 8 pericranial muscles are palpated by the investigator and the tenderness is rated by the participant on a scale of 0-3 where 0 is no tenderness and 3 is severe tenderness.
Time frame: 3 hours
Cold Pressor Test: Pain Tolerance
Difference in Cold Pressor Test Pain Tolerance (seconds) between cases and controls
Time frame: 3 hours
Cold Pressor Test: Pain Rating
Difference in Cold Pressor Test Pain Rating by Verbal Rating Scale (VRS) between cases and controls. The pain is rated by the participant on the Verbal Rating Scale from 0 - 10 where 0 is no pain and 10 is the most severe pain imaginable.
Time frame: 3 hours
Plan to share: Undecided
This study is completed, as verified in Mar 2021. You cannot join it, but the record below documents what was studied.
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Danish Headache Center