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CompletedNCT04215263Updated Feb 21, 2020

Risk Factors of POCD in General Anesthesia Patients Underwent Noncardiac and Non Neurological Procedures.

An observational study in Undergoing General Anaesthesia, sponsored by Indonesia University. Completed at 1 site in Indonesia. Open to participants aged 60 Years and older. Per ClinicalTrials.gov, last updated 2020-02-21.

Sponsored by Indonesia University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
109
Ages
60 Years and older
Sex
All
01

Study summary

The study was a prospective cohort study to assess the effect of age, duration of anesthesia, repeated surgery, and type of surgery on cognitive impairment in 108 geriatric patients (≥60 years) who underwent general anesthesia for non-neurologic noncardiac surgery.

Read the detailed description

The study was a prospective cohort study, assessing the effect of age, duration of anesthesia, repeated surgery, and type of surgery on cognitive impairment in 108 geriatric patients (≥60 years) who underwent general anesthesia for non-neurologic noncardiac surgery. The study used cognitive tests such as RAVLT, TMT, and Digit span tests. POCD definition is reduction in postoperative cognitive function by as much as 20% at a minimum of 2 cognitive tests.

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Conditions studied

  • Undergoing General Anaesthesia

Keywords

  • postoperative cognitive dysfunction
  • geriatrics
  • general anaesthesia
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In context

Cognitive Dysfunction

3,843 studies on the registry are indexed under Cognitive Dysfunction; 1,100 are open to participants now.

This study's enrollment of 109 is below the median of 150 across 950 observational studies indexed under Cognitive Dysfunction.

Browse Cognitive Dysfunction studies →

Lead sponsor

Indonesia University is the lead sponsor of 448 studies on the registry; 56 are open to participants now.

Of its 6 completed or terminated interventional studies of FDA-regulated products, 1 (17%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
60 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Geriatric patient (age over 60) underwent noncardiac non-neurological procedure under general anesthesia

Inclusion criteria

  • geriatric patient (age over 60) underwent noncardiac non-neurological procedure under general anesthesia
  • patient can do reading and writing
  • patient can speak in Bahasa
  • signing informed consent

Exclusion criteria

Exclusion Criteria:

  • patient with cognitive impairment or psychiatric disorder such as delirium, amnesia, anxiety disorder, or depression.
  • patient under psychotropic drugs or narcotics.
  • patient with history of brain tumor, head injury or motoric disturbance and disability that can disturbed neurocognitive test
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
109 participants (actual)
Patient registry
No

Groups and cohorts

  • Geriatric patient underwent general anesthesia procedure

    geriatric patients (≥60 years) ware assessed for cognitive impairment after general anesthesia for non-neurologic noncardiac surgery.

    Other: Questionaire

Interventions

  • OtherQuestionaire

    Patient was assessed using mini international neuropsychiatric interview

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What researchers measure

Primary outcomes

  1. Mini International Neuropsychiatric Interview

    Score was assessed using 6 forms

    Time frame: 7 days

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Study locations

1 site
  • Indonesia University
    Jakarta, DKI Jakarta 10430, Indonesia
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References and documents

Publications

  • BEDFORD PD. Adverse cerebral effects of anaesthesia on old people. Lancet. 1955 Aug 6;269(6884):259-63. doi: 10.1016/s0140-6736(55)92689-1. No abstract available. PubMed 13243706 ↗
  • Strom C, Rasmussen LS, Sieber FE. Should general anaesthesia be avoided in the elderly? Anaesthesia. 2014 Jan;69 Suppl 1(Suppl 1):35-44. doi: 10.1111/anae.12493. PubMed 24303859 ↗
  • Rundshagen I. Postoperative cognitive dysfunction. Dtsch Arztebl Int. 2014 Feb 21;111(8):119-25. doi: 10.3238/arztebl.2014.0119. PubMed 24622758 ↗
  • Canet J, Raeder J, Rasmussen LS, Enlund M, Kuipers HM, Hanning CD, Jolles J, Korttila K, Siersma VD, Dodds C, Abildstrom H, Sneyd JR, Vila P, Johnson T, Munoz Corsini L, Silverstein JH, Nielsen IK, Moller JT; ISPOCD2 investigators. Cognitive dysfunction after minor surgery in the elderly. Acta Anaesthesiol Scand. 2003 Nov;47(10):1204-10. doi: 10.1046/j.1399-6576.2003.00238.x. PubMed 14616316 ↗
  • van Harten AE, Scheeren TW, Absalom AR. A review of postoperative cognitive dysfunction and neuroinflammation associated with cardiac surgery and anaesthesia. Anaesthesia. 2012 Mar;67(3):280-93. doi: 10.1111/j.1365-2044.2011.07008.x. PubMed 22321085 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 21, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04215263
Lead sponsor
Indonesia University
Responsible party
Aries Perdana (Principal Investigator, Indonesia University) — Principal investigator
First posted
Jan 2, 2020
Start date
May 1, 2019
Primary completion
Jul 5, 2019
Completion
Jul 5, 2019
Last update
Feb 21, 2020

Study contacts

Aries Perdana, MD
principal investigator · Indonesia University

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2020. You cannot join it, but the record below documents what was studied.

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