An observational study in Acute Kidney Injury, Hypoperfusion and Fluid Overload, sponsored by Aarhus University Hospital. Terminated at 1 site in Denmark. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-12-09.
Sponsored by Aarhus University Hospital · Observational
The study will examine the ability of renal ultrasound (Doppler and Contrast Enhanced Ultrasound (CEUS)) in distinguishing ICU patients who exhibit increases in glomerular filtration rate (GFR) in response to fluid loading, from those for whom fluid loading is without benefit of directly harmful.
The study will examine the ability of renal ultrasound (Doppler and Contrast Enhanced Ultrasound (CEUS)) in distinguishing ICU patients who exhibit increases in GFR in response to fluid loading, from those for whom fluid loading is without benefit of directly harmful.
Patients available for inclusion will receive a baseline administration of Tc-99-DTPA for precise determination of GFR/renal function by blood and urine samples.
Baseline values of ultrasound measures will be obtained, including renal arterial, renal venous, portal venous and hepatic venous Doppler measures and renal contrast enhanced ultrasound (CEUS) will also be recorded.
After two hours, baseline values of GFR are finished. The patient is then exposed to passive leg raising and ultrasound measures are repeated, including renal arterial, renal venous, portal venous and hepatic venous Doppler measures.
The participant then receives a standardised fluid bolus of 7 ml/kg (ideal body weight) Once the fluid bolus administration is complete, renal ultrasound is repeated, including renal arterial, renal venous, portal venous, hepatic venous Doppler measures and renal CEUS.
Follow-up determination of GFR/renal function based on Tc-99-DTPA after fluid therapy is repeated with blood and urine samples.
1,595 studies on the registry are indexed under Acute Kidney Injury; 371 are open to participants now.
This study's enrollment of 2 is below the median of 150 across 773 observational studies indexed under Acute Kidney Injury.
Browse Acute Kidney Injury studies →Aarhus University Hospital is the lead sponsor of 289 studies on the registry; 79 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All patients admitted to the ICU at Aarhus University Hospital
Exclusion Criteria:
ICU patients who are assessed by their attending physician as having need for fluid therapy and are planned to receive IV crystalloid fluid due to oliguria and/or to improve GFR.
Drug: IV crystalloid fluid bolus
The participant receives IV fluid as a standardised bolus of 7 ml/kg (ideal body weight).
Changes in renal function in response to a standardised fluid bolus.
Renal function is measures as Tc-99-Diethylenetriaminepentaacetic acid (DTPA) clearance.
Time frame: 6 hours
Renal venous flow classification
normal - abnormal (pulsatile/biphasic/monophasic
Time frame: 6 hours
Renal venous impedance index
(maximum flow velocity - minimum diastolic flow velocity) / maximum flow velocity
Time frame: 6 hours
Renal venous stasis index
(index cardiac cycle time - venous flow time) / index cardiac cycle time
Time frame: 6 hours
Renal arterial resistive index
(maximum flow velocity - minimum diastolic flow velocity) / maximum flow velocity
Time frame: 6 hours
Portal venous pulsatility fraction
(maximum flow velocity - minimum diastolic flow velocity) / maximum flow velocity
Time frame: 6 hours
Contrast enhanced ultrasound 1
Mean transit time (mTT)
Time frame: 6 hours
Contrast enhanced ultrasound 2
Perfusion Index (PI)
Time frame: 6 hours
Contrast enhanced ultrasound 3
Relative Blood Volume (rBV)
Time frame: 6 hours
Contrast enhanced ultrasound 4
Wash-in Rate (WiR)
Time frame: 6 hours
Contrast enhanced ultrasound 5
Quality Of Fit (QOF)
Time frame: 6 hours
Continuous recordings of hemodynamic variables 1
arterial pressure
Time frame: 6 hours
Continuous recordings of hemodynamic variables 2
Central venous pressure
Time frame: 6 hours
Plan to share: No
No publications or documents are linked to this record.
This study is terminated, as verified in Dec 2020. You cannot join it, but the record below documents what was studied.
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Aarhus University Hospital