An interventional study of Control and SIT+E in Sedentary Behavior, sponsored by University of Nottingham. Completed at 1 site in United Kingdom. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-03-30.
Sponsored by University of Nottingham · Not applicable, Interventional, and Basic science
Physical inactivity is a significant predictor of major non-communicable diseases such as type 2 diabetes (7%), cardiovascular disease (6%), musculoskeletal disorders and some cancers, and has been proposed to be the 4th leading cause of death worldwide. Reduced physical activity leads to an impaired function of the hormone insulin and increased adiposity. Thus, the elimination of physical inactivity would remove between 6% and 10% of the major non-communicable diseases and increase life expectancy. The aim of the study is to investigate the effects of a short-term (2-day) period of reduced physical activity, with and without a proportional decrease in energy intake, on the action of insulin to regulate blood sugar fluctuations, appetite, and cardiovascular parameters (heart rate, cardiac output, stroke volume, blood flow, arterial blood pressure, peripheral vascular resistance) in response to food ingestion.
367 studies on the registry are indexed under Sedentary Behavior; 165 are open to participants now.
This study's enrollment of 8 is below the median of 70 across 314 interventional studies indexed under Sedentary Behavior.
Browse Sedentary Behavior studies →University of Nottingham is the lead sponsor of 463 studies on the registry; 78 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
2 consecutive days of standardised daily levels of moderate physical activity (PAL=1.85 reflecting their habitual levels), and matched energy (food) intake
Other: Control
2 consecutive days of reduced physical activity induced by prolonged periods of sitting (PAL=1.4) whilst maintaining the level of food intake prescribed in the Control trial, thus creating a positive energy balance
Other: SIT+E
2 consecutive days of reduced physical activity induced by prolonged periods of sitting (PAL=1.4) whilst reducing food intake to match the reduction in energy expenditure induced by inactivity, thus maintaining energy balance
Other: SIT=E
Normal physical activity and standard energy intake
Reduced physical activity and standard energy intake
Reduced physical activity and reduced energy intake
The incremental area under curve for Insulin
The incremental area under curve for Insulin will be calculated using samples collected at 20 minute intervals between baseline and three hours
Time frame: Over three hours from baseline
The incremental area under curve for arterialized whole blood glucose
The incremental area under curve for arterialized whole blood glucose will be calculated using samples collected at 10 minute intervals between baseline and four hours
Time frame: Over four hours from baseline
The incremental area under curve for free fatty acids
The incremental area under curve for free fatty acids will be calculated using samples collected at 20 minute intervals between baseline and three hours
Time frame: Over three hours from baseline
The incremental area under curve for Triglycerides
The incremental area under curve for Triglycerides will be calculated using samples collected at 20 minute intervals between baseline and three hours
Time frame: Over three hours from baseline
The incremental area under curve for Ghrelin
The incremental area under curve for Ghrelin will be calculated using samples collected at one hour intervals between baseline and four hours
Time frame: Over four hours from baseline
The incremental area under curve for composite satiety score
Composite satiety score will be calculated using 100mm visual analogue score ratings of satiety, fullness, hunger, desire to eat and prospective food consumption collected every 20 minutes between baseline and four hours.
Time frame: Over four hours from baseline
Weight of consumption of a pasta meal three hours after baseline
Weight of pasta consumed from a bowel refilled prior to being empty until participants feel comfortably full
Time frame: Three hours post baseline
The incremental area under curve for cardiovascular parameters
The incremental area under curve for mean blood pressure,cardiac output, stroke volume, peripheral resistance, heart rate, systolic blood pressure and diastolic blood pressure continuously over three hours from baseline using Finometer
Time frame: Over three hours from baseline
The incremental area under curve for limb blood flow
The incremental area under curve for limb blood flow measured at 30 minute intervals between baseline and three hours using venous occlusion plethysmography
Time frame: Over three hours from baseline
Plan to share: No — only anonymised individual personal data will be shared, upon specific request from other researchers, for example, in order to undertake a meta analysis
No publications or documents are linked to this record.
This study is completed, as verified in Nov 2019. You cannot join it, but the record below documents what was studied.
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