An observational study in Cardiac Arrest, sponsored by AfterROSC. Completed at 27 sites in 2 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-09-26.
Sponsored by AfterROSC · Observational
Even in patients with successful return of spontaneous circulation (ROSC), outcome after cardiac arrest remains poor. The overall in-hospital survival rate widely varies both worldwide and across communities, from 1 to 4 folds according to circumstances of arrest and post-resuscitation interventions. Several studies have already shown that early interventions performed after ROSC, such as treatment of the cause, targeted temperature management, optimal hemodynamic management and extra-corporeal life support in selected patients, could improve the outcome in post-cardiac arrest patients. However, the decision process regarding the allocation of these resources, in parallel with the management of patients' proxies, remains a complex challenge for physicians facing these situations. Consequently, several prediction models and scores have been developed in order to stratify the risk of unfavorable outcome and to discriminate the best candidates for post-resuscitation interventions. Overall, several scores exist, but external validation are lacking and direct comparisons are needed to assess relative interest of scoring systems. Indeed, establishing the optimal scoring system is crucial, for optimal treatment allocation and appropriate information to relatives.
2,113 studies on the registry are indexed under Brain Injuries; 385 are open to participants now.
This study's enrollment of 1,144 is above the median of 100 across 690 observational studies indexed under Brain Injuries.
Browse Brain Injuries studies →AfterROSC is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
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This is an observational, prospective, multicentric prognostic study. The study period is 1 year, and we plan to include 597 patients in 21 ICUs in France.
For all patients included, medical history, clinical data, paraclinical results and outcome (at hospital discharge and at 3 months, including modified Rankin score) will be prospectively collected by local investigator, according to an electronical CRF.
Exclusion Criteria:
Patients with return of spontaneous circulation after cardiac arrest regardless of initial rhythm, and admitted in intensive care unit for post cardiac arrest care
Diagnostic Test: Calculation of early prognosis score
Early prognosis score will be calculated at intensive care unit admission for each patient based on clinical and biological values as required
Determination of Area Under Curve of Cerebral Admission Hospital Prognosis (CAHP) Score at intensive care unit admission
Determination of AUC for CAHP score as compare to Utstein style criteria. CAHP score range from 0 to 300 with higher score indicates poorer prognosis
Time frame: Intensive Care Unit Admission (Usually 3 hours after cardiac arrest)
Determination of Area Under Curve of modified CAHP Score at intensive care unit admission
Determination of AUC for modified CAHP score as compare to Utstein style criteria mCAHP score range from 0 to 280 with higher score indicates poorer prognosis
Time frame: Intensive Care Unit Admission (Usually 3 hours after cardiac arrest)
Determination of Area Under Curve of simplified CAHP Score at intensive care unit admission
Determination of AUC for simplified CAHP score as compare to Utstein style criteria sCAHP score range from 0 to 150 with higher score indicates poorer prognosis
Time frame: Intensive Care Unit Admission (Usually 3 hours after cardiac arrest)
Determination of Area Under Curve of OHCA Score at intensive care unit admission
Determination of AUC for OHCA score as compare to Utstein style criteria OHCA score range from -30 to 60 with higher score indicates poorer prognosis
Time frame: Intensive Care Unit Admission (Usually 3 hours after cardiac arrest)
Determination of Area Under Curve of CREST Score at intensive care unit admission
Determination of AUC for CREST score as compare to Utstein style criteria CREST score range from 0 to 5 with higher score indicates poorer prognosis
Time frame: Intensive Care Unit Admission (Usually 3 hours after cardiac arrest)
Determination of Area Under Curve of C-Graph Score at intensive care unit admission
Determination of AUC for C-Graph score as compare to Utstein style criteria C-Graph score range from 0 to 5 with higher score indicates poorer prognosis
Time frame: Intensive Care Unit Admission
Determination of Area Under Curve of TTM Score at intensive care unit admission
Determination of AUC for TTM score as compare to Utstein style criteria TTM score range from -2 to 35 with higher score indicates poorer prognosis
Time frame: Intensive Care Unit Admission (Usually 3 hours after cardiac arrest)
Determination of Area Under Curve of NULL-PLEASE Score at intensive care unit admission
Determination of AUC for NULL-PLEASE score as compare to Utstein style criteria NULL-PLEASE score range from 0 to 14 with higher score indicates poorer prognosis
Time frame: Intensive Care Unit Admission (Usually 3 hours after cardiac arrest)
Determination of calibration of each score
Determination of calibration of: CAHP, sCAHP, mCAHP, OHCA, CREST, C-Graph, TTM and NULL-PLEASE score
Time frame: Intensive Care Unit Admission (Usually 3 hours after cardiac arrest)
Plan to share: No
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This study is completed, as verified in Sep 2024. You cannot join it, but the record below documents what was studied.
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AfterROSC