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CompletedNCT04149028Updated Feb 17, 2023

Platelet Rich Plasma Injection Into Ovary of Patients With Premature Ovarian Insufficiency

An interventional study of PRP injection inside the ovary by laparoscoy. The injection volume is 2 ml in Premature Ovarian Failure, sponsored by Tanta University. Completed at 1 site in Egypt. Open to female participants aged 18 Years to 35 Years. Per ClinicalTrials.gov, last updated 2023-02-17.

Sponsored by Tanta University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
16
Allocation
Not applicable
Ages
18 Years to 35 Years
Sex
Female
01

Study summary

All encountered cases with POI will be assessed and examined then investigated. Eligible cases will be included in the study

Read the detailed description

Patients will be subjected to injection of autologous PRP inside the ovary about 0.5-1 mml by laparoscopy

02

Conditions studied

  • Premature Ovarian Failure

Keywords

  • Premature ovarian insuffiency
  • Infertility
  • PRP
03

In context

Premature Birth

2,553 studies on the registry are indexed under Premature Birth; 498 are open to participants now.

This study's enrollment of 16 is below the median of 84 across 1,688 interventional studies indexed under Premature Birth.

Browse Premature Birth studies →

Lead sponsor

Tanta University is the lead sponsor of 963 studies on the registry; 304 are open to participants now.

Of its 16 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Inclusion criteria

  • Premature ovarian insufficiency diagnosed by:
  • FSH> 40 Amenorrhea Menopuasal symptoms Infertility

Exclusion criteria

Exclusion Criteria:

  • Refusal to participate Secondary POI due chemotherapy, surgery, or radiotherapy Previous treatment with PRP
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
16 participants (actual)

Study arms

  • Experimental
    PRP injection

    injection of PRP inside ovary by the assistance of laparoscopy

    Procedure: PRP injection inside the ovary by laparoscoy. The injection volume is 2 ml

Interventions

  • ProcedurePRP injection inside the ovary by laparoscoy. The injection volume is 2 ml

    intraovarian injection of 2 mml of PRP by laparoscopic guide

06

What researchers measure

Primary outcomes

  1. Resumption of ovarian hormonal function

    Measurement of Estradiol level on Day 3 of cycle

    Time frame: 3-6 months

  2. Resumption of ovarian folliclugenesis

    Assessment of the presence of oocytes by trans vaginal ultrasound on day 3

    Time frame: 3-6 months

Secondary outcomes

  1. Resumption of menstruation

    Occurrence of Menstruation after secondary amenrorrhea by questionnaire

    Time frame: 3-6 months

  2. Fertility potential

    Potential to get pregnant after ICSI procedure

    Time frame: 3-6 months

07

Study locations

1 site
  • Adel Elgergawy
    Tanta, Egypt
08

References and documents

Individual participant data

Plan to share: Undecided — we will decide later

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 17, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04149028
Lead sponsor
Tanta University
Responsible party
Ayman S Dawood, MD (Lecturer of Obstetrics and gynecology, Tanta University) — Principal investigator
First posted
Nov 4, 2019
Start date
Dec 1, 2019
Primary completion
Dec 31, 2022
Completion
Dec 31, 2022
Last update
Feb 17, 2023

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2023. You cannot join it, but the record below documents what was studied.

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