An observational study in Cognitive Impairment, Stroke and Albumin; Double, sponsored by Dongguan People's Hospital. Completed at 1 site in China. Open to participants aged 40 Years to 80 Years. Per ClinicalTrials.gov, last updated 2019-10-24.
Sponsored by Dongguan People's Hospital · Observational
This registration enrolled patients with acute ischemic stroke within 72 hours after stroke ictus. Patients was identified as first-ever stroke based on past medical histrory. Admission CT was conducted to exclude hemorrhagic stroke, but not those bleeding transformation after ischemia injury. Baseline characteristics, including demographics, vascular risk factors, lab tests and neuroimagings were collected. Patients were followed up for cognitive assessments.
This is a perspective stroke registry cohort study. Stroke patients were included if ：(1) acute first-ever ischemic stroke and admitted within 72 hours after onset; (2) clinical stroke diagnosis was confirmed with positive diffusion-weighted magnetic resonance imaging (DW-MRI), those with isolated posterior circulations infarcts were exclude ; (3) presented with mild stroke severity ( admission NIHSS score ≤5); (4) age between 40 and 80 years.
Clinical data including demographic characteristics, risk factors, and baseline NIHSS score were assessed and collected using a standardized table by experienced neurologists. Lab tests were performed with fasting venous blood samples within 18 hours of admission.
Patients were followed up for 6 months. The cognitive functions were assessed using the Chinese version of Montreal Cognitive Assessment (MoCA).
Contributing factors to post-stroke cognitive impariment (PSCI) were determined by comparing clinical data between PSCI and non-PSCI groups. All potential confounders were introduced into the multivariate regression models.
7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.
This study's enrollment of 435 is above the median of 160 across 1,692 observational studies indexed under Stroke.
Browse Stroke studies →Dongguan People's Hospital is the lead sponsor of 6 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients were continuously enrolled from a perspective stroke registry between January 1, 2017 and June 31, 2018, in Dongguan People's Hospital, Guangdong, China.
Exclusion Criteria:
hypoalbuminemia was classified as serum albumin level (SAL) \<35g/L
Other: strengthened nuitritional treatment
patients with serum albumin level (SAL) of 35g/L or higher
improving nutritional status by nasal feeding for dysphagia or iv. albumin when serum albumin level lower than 35g/L
PSCI
Patients with a MoCA score of \<24 were categorized as having PSCI
Time frame: 6 months post-stroke
Plan to share: Undecided — The final decision to release IPD is still pending because of the ongoing census among all paticipants's decision.
No publications or documents are linked to this record.
This study is completed, as verified in Oct 2019. You cannot join it, but the record below documents what was studied.
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Dongguan People's Hospital