An interventional study of Emotional Awareness and Expression Therapy in Somatic Symptom Disorder, sponsored by Karolinska Institutet. Completed at 1 site in Sweden. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-04-16.
Sponsored by Karolinska Institutet · Not applicable, Interventional, and Treatment
Among 13 studies in Medically Unexplained Symptoms with a site in Sweden — 1 open to participants now, 1 under way, none of them phase 3. Medically Unexplained Symptoms · Sweden.
Among the 13 studies in Medically Unexplained Symptoms with a site in Sweden, this one is the 8th largest by enrollment, is the only one that started in 2019, is one of 13 with no phase, and was the 4th registered.
71 studies on the registry are indexed under Medically Unexplained Symptoms; 22 are open to participants now.
This study's enrollment of 50 is below the median of 68 across 53 interventional studies indexed under Medically Unexplained Symptoms.
Browse Medically Unexplained Symptoms studies →1 of the 13 studies in Medically Unexplained Symptoms with a site in Sweden is open now, in 1 country. Each count lists the studies.
Of the 20 Medically Unexplained Symptoms studies recruiting now, 6 (30%) set no upper age limit and 12 (60%) stop at 75 or younger; 6 take children under 18; 9 take healthy volunteers.
This study: 18 Years and older · all sexes · healthy volunteers too.
The full table on the hub →13 studies; the count open now beside each. This study's row is marked.
First in 2010; this study’s year is marked. 1 started in 2019.
Median enrollment 120 across the 13 interventional studies. Of the 11 that completed or were terminated, 1 (9%) have results posted.
None of the 13 has an industry lead sponsor. The 4 most frequent:
Karolinska Institutet is the lead sponsor of 1,148 studies on the registry; 276 are open to participants now.
Karolinska Institutet has 5 studies filed under Medically Unexplained Symptoms — fewer than ten, so there is no comparison to draw.
None of the studies under way reaches primary completion within a year.
Among the 13 studies in Medically Unexplained Symptoms with a site in Sweden, from their registry updates:
Nothing recorded among them since 2026-09-25.
The main purpose of the study is to conduct an initial feasibility evaluation of the new Internet-based EAET treatment manual. We will include 50 patients with somatic symptom disorder to take part of the treatment for nine weeks through the Internet. A within-subject design will be used. Self-report measures of symptom level and mechanisms of change will be conducted weekly. Feedback on content, process and potential caveats will be collected using surveys and written evaluations from the participants at post-treatment. Linear mixed models will be used to investigate trajectories of change in symptoms and processes.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Internet-based Emotional Awareness and Expression Therapy
Behavioral: Emotional Awareness and Expression Therapy
Very much based on "Unlearn your pain" by Howard Schubiner.
PHQ-15
Patient Health Questionnaire Physical Symptoms
Time frame: Baseline
PHQ-15
Change in physical symptoms (as measured by the PHQ-15)
Time frame: Weekly during treatment, for 9 weeks
PHQ-15
Patient Health Questionnaire Physical Symptoms
Time frame: At study completion, after 9 weeks
PHQ-15
Patient Health Questionnaire Physical Symptoms
Time frame: At study completion, after 4 months
PHQ-9
Patient Health Questionnaire Depression
Time frame: Baseline
PHQ-9
Patient Health Questionnaire Depression
Time frame: At study completion, after 9 weeks
PHQ-9
Patient Health Questionnaire Depression
Time frame: At study completion, after 4 months
GAD-7
Patient Health Questionnaire Anxiety
Time frame: Baseline
GAD-7
Patient Health Questionnaire Anxiety
Time frame: At study completion, after 9 weeks
GAD-7
Patient Health Questionnaire Anxiety
Time frame: At study completion, after 4 months
SDS
Sheehan Disability Scale
Time frame: Baseline
SDS
Sheehan Disability Scale
Time frame: At study completion, after 9 weeks
SDS
Sheehan Disability Scale
Time frame: At study completion, after 4 months
EPS-25
Emotional Processing Scale (Measure of treatment process)
Time frame: Baseline
EPS-25
Emotional Processing Scale (Measure of treatment process)
Time frame: Weekly during treatment, for 9 weeks
EPS-25
Emotional Processing Scale (Measure of treatment process)
Time frame: At study completion, after 9 weeks
EPS-25
Emotional Processing Scale (Measure of treatment process)
Time frame: At study completion, after 4 months
Plan to share: No
Ran from Sep 2019 to primary completion in Apr 2020, 6 months.
Of 33 non-industry interventional studies with no phase under Medically Unexplained Symptoms, half reached primary completion within 29 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 43. This study's 6 months is below that.
Counting every sponsor, half of 33 studies reached it within 29 months; a quarter within 10 and three quarters within 43.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Apr 2020. You cannot join it, but the record below documents what was studied.
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Medically Unexplained Symptoms →