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CompletedNCT04119765OXAGOUpdated Jul 21, 2022

Plasma Oxalate in Patient With Short Bowel

An observational study in Short Bowel Syndrome, Hyperoxaluria and Hyperoxalemia, sponsored by Hospices Civils de Lyon. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-07-21.

Sponsored by Hospices Civils de Lyon · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
47
Ages
18 Years and older
Sex
All
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Study summary

Hyperoxaluria due to fat malabsorption is seen in patients suffering from short bowel and can lead to stones and nephrocalcinosis. Not all patients are prone to these renal complications. only urinary oxaluria is measured in practice. Plasma oxalate shouldn't increase theoretically in these patients. However recent report showed an increase of plasma oxalate in patient with enteric hyperoxaluria. The aim of this study is to assess the plasma oxalate distribution in this specific population to have a new tool to predict renal complication of these patients.

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Conditions studied

  • Short Bowel Syndrome
  • Hyperoxaluria
  • Hyperoxalemia

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03

In context

Short Bowel Syndrome

149 studies on the registry are indexed under Short Bowel Syndrome; 25 are open to participants now.

This study's enrollment of 47 is below the median of 53 across 36 observational studies indexed under Short Bowel Syndrome.

Browse Short Bowel Syndrome studies →

Lead sponsor

Hospices Civils de Lyon is the lead sponsor of 1,826 studies on the registry; 439 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

type II short bowel patient

Inclusion criteria

  • Age ≥ 18 years
  • Type II short bowel for more than 6 months
  • Affiliated to a social health care

Exclusion criteria

Exclusion Criteria:

  • Primary hyperoxaluria
  • Other type of short bowel than type II
  • Minor patient or major patient protected by the law
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
47 participants (actual)
Patient registry
No

Interventions

  • BiologicalBlood sampling

    blood sampling will be used to perform oxalemia and FGF23 quantitative analysis

  • BiologicalUrine sampling

    urine sampling will be used to measure glycolate urinary rate (glycolaturia) and to perform urinary inflammation markers quantitative analysis

  • ProcedurePulse Wave Velocity (PWV) measurement

    PWV will be measured thank to the Complior® device

  • Procedurecentral pressure measurement

    central pressure will be measured thank to the Complior® device

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What researchers measure

Primary outcomes

  1. Plasma oxalate rate (oxalemia)

    this sample measures the plasma oxalate rate

    Time frame: at inclusion

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Study locations

1 site
  • Nephrology Department, Edouard Herriot Hospital
    Lyon, 69003, France
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 21, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04119765
Lead sponsor
Hospices Civils de Lyon
Responsible party
Sponsor
First posted
Oct 8, 2019
Start date
Feb 27, 2020
Primary completion
May 4, 2022
Completion
May 4, 2022
Last update
Jul 21, 2022

Study contacts

Sandrine Lemoine, MD
principal investigator · Hospices Civils de Lyon

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.

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