An interventional study of Questionnaires and Semi-structured individual interviews in Metastatic Uveal Melanoma, Triple Negative Breast Cancer and Luminal B Breast Cancer, sponsored by Institut Curie. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-09-19.
Sponsored by Institut Curie · Not applicable, Interventional, and Other
Resistance to treatment is one of the major themes in cancer research. Despite this, the definition and clinical implications of resistance to treatment remain under-explored, and patient-physician communication in this context still constitutes a challenge. When resistance to cancer treatments occurs, physicians not only have to explain to the patient the phenomenon of resistance, often based on complex results (biological results, genomic tests, imaging, etc.), but also need to offer alternative therapies, whilst fostering shared medical decision-making. These different tasks are particularly challenging for clinicians, especially since there are large individual differences at patient level. Indeed, each patient has his or her own unique information needs, capacity for understanding, and level of desire to participate in treatment decisions.
Although a challenge, better communicating around resistance to treatment carries many potential benefits. Indeed, in similar contexts of announcement of bad news and choice of care, Parker and collaborators (1) have highlighted the positive impact of individualized care, respecting the needs, quality of care, and quality of life of patients. Given the clinical stake, and the lack of scientific knowledge devoted to communication in the context of resistance to treatment, it appears necessary to better understand its modalities. In this perspective, research has proven the value of tools for supporting communication, including the issue of question booklets for patients. These tools provide patients with a list of questions submitted to them before the medical consultation, and which they can ask during the consultation, and throughout the treatment. This tool fosters communication by helping the patient obtain a level of information that is adapted to his or her needs and experience, and thus, to be better prepared for care. Despite significant interest for these booklets in the field of oncology, none has yet been developed in the specific context of resistance to treatment.
103 studies on the registry are indexed under Uveal Melanoma; 38 are open to participants now.
This study's enrollment of 128 is above the median of 42 across 93 interventional studies indexed under Uveal Melanoma.
Browse Uveal Melanoma studies →Institut Curie is the lead sponsor of 134 studies on the registry; 28 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients:
Parents of a sick child:
Expert patients:
Professionals:
Exclusion Criteria:
Patients \& parents of a sick child:
Expert patients:
Professionals:
Questionnaires and semi-structured individual interviews with patients with Metastatic Uveal Melanoma
Behavioral: Questionnaires · Behavioral: Semi-structured individual interviews
Questionnaires and semi-structured individual interviews with patients with Triple Negative Breast Cancer
Behavioral: Questionnaires · Behavioral: Semi-structured individual interviews
Questionnaires and semi-structured individual interviews with patients with Luminal B Breast Cancer
Behavioral: Questionnaires · Behavioral: Semi-structured individual interviews
Questionnaires and semi-structured individual interviews with parents of children with cancer.
Behavioral: Questionnaires · Behavioral: Semi-structured individual interviews
Focus groups (or group interviews) and DELPHI consensus method with expert patients
Other: Focus Group · Other: DELPHI Consensus Method
Focus groups (or group interviews) and DELPHI consensus method with Researchers and Clinicians
Other: Focus Group · Other: DELPHI Consensus Method
Questionnaires
Semi-structured individual interviews
Focus Group
DELPHI Consensus Method
List of patients' needs, particularly regarding communication with physicians
List of patients' needs in support, and information delivered by physicians in consultation
Time frame: 18 months
Items of communication booklet
Number and content of items, number of categories / themes,
Time frame: 18 months
Acceptability of the booklet evaluated
Items and issues revised and reformulated by the experts. Application of the booklet in the determined clinic: Modes of administration of the booklet and patients concerned identified. Implementation of the tool and relevant patients identified
Time frame: 18 months
Content of communication booklet validated
Consensus criteria: Consensus can be considered to have been reached if the majority of participants (70% or more) rank an item similarly
Time frame: 18 months
Plan to share: Yes — Investigators will share de-identified data sets with interested reserachers, educators or clincians. Materials generated under the project will be disseminated in accordance with Institut Curie policies.
This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Institut Curie