An interventional study of Screening and Inclusion in Bronchopulmonary Disease and Diagnoses Disease, sponsored by Institut Curie. Recruiting at 9 sites in France. Open to participants aged 50 Years to 74 Years. Per ClinicalTrials.gov, last updated 2026-09-10.
Sponsored by Institut Curie · Not applicable, Interventional, and Diagnostic
The aim of this study is to evaluate the feasibility of performing a first screening for bronchopulmonary cancer by thoracic scanner in a French cohort within a dedicated, effective and structured network in the pilot centers participating in the study.
The organization of bronchopulmonary cancer screening in the Ile de France region, within the Mutualists and its affiliated health centers, is based on a clear, simple and functional process:
Institut Curie is the lead sponsor of 135 studies on the registry; 29 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Active smoker or quit smoker for 10 years or less:
Exclusion Criteria:
Screening CTscan according to the NELSON trial schedule (at inclusion, 1 year, 3 years, 5.5 years),
Other: Screening · Other: Inclusion · Other: Chest CTscan and follow-up
A first step to identify and recruit people eligible for screening,
A second step for inclusion of participants, with an online self-questionnaire and information, and an inclusion visit to the health center,
A third step with an initial CTscan, with dual interpretation and appropriate management of participants, including follow-up care.
Rate of first CTscan for bronchopulmonary cancer screening
Rate of completion of a first bronchopulmonary cancer screening among people who have joined the program (i.e. registered on the program's web platform and met the inclusion criteria).
Time frame: 36 months
Eligibility rate among people registering on the web platform
Ratio of the number of eligible people (meeting all inclusion and inclusion criteria and no non-inclusion criteria) to the total number of people registered on the web platform.
Time frame: 36 months
Rate of completion of the inclusion visit among people registered on the web platform,
Ratio of the number of people who have completed the inclusion visit to the total number of eligible people registered on the web platform
Time frame: 36 months
Rate of completion of screening scanners at 1 year according to NELSON trial schedule
Ratio of the number of people who had their 1-year screening CTscan among those eligible for a 1-year CTscan
Time frame: 48 months
Rate of completion of screening scanners at 3 years according to NELSON trial schedule
Ratio of the number of people who had their 3-year screening CTscan among those eligible for a 3-year CTscan
Time frame: 72 months
Rate of completion of screening scanners at 5.5 years according to NELSON trial schedule
Ratio of the number of people who had their 5.5-year screening CTscan among those eligible for a 5.5-year CTscan
Time frame: 102 months
Correlation of demographic characteristics and the detection of a nodule during the 4 CTscan
Demographic characteristics at inclusion will be compared between people who have or have not had at least one nodule detected on one of the 4 CTscan.
Time frame: 102 months
Rate of complications related to complementary explorations
Ratio between the number of people with complications related to complementary explorations and the population having undergone a CT scan.
Time frame: 102 months
Smoking cessation rates during the screening program
The rate of newly non-smoking subjects will be calculated for each type of approach by dividing the number of newly non-smoking subjects by the number of subjects people included in the study.
Time frame: 102 months
Rate of early-stage bronchopulmonary cancers identified
Number of bronchopulmonary cancers detected at an early stage (stage I or stage II) to the total number of people who underwent a CTscan at inclusion
Time frame: 102 months
Rate of positive screening without bronchopulmonary cancer
The rate of false-positive screening will be calculated by people who have at least one positive screening scanner, but whose histology has not confirmed their malignancy, to the number people who had a scanner
Time frame: 102 months
Plan to share: Yes — Sponsor will share de-identified data sets. Documents generated under the project will be disseminated in accordance with Institut Curie policies.
Supporting information: Study protocol, Statistical analysis plan
Time frame: Data requests can be submitted starting 9 months after last article publication and will be made accessible for up to 12 months.
Access criteria: Access to trial individual participant data can be requested by qualified researchers engaging in independent scientific research, and will be provided following review and approval of a research proposal and Statistical Analysis Plan (SAP) and execution of a data sharing agreement (DSA).
No publications or documents are linked to this record.
Started Jan 2025 (actual). Primary completion is estimated for Feb 2033, 96 months after the start.
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