An observational study in Bronchopulmonary Dysplasia, Chronic Lung Disease of Newborn and Environmental Exposure, sponsored by Boston Children's Hospital. Completed at 1 site in United States. Open to participants aged 6 Years to 12 Years. Per ClinicalTrials.gov, last updated 2026-05-06.
Sponsored by Boston Children's Hospital · Observational
Investigators want to learn the role of indoor environmental exposures on respiratory symptoms, and, separately, on lung function deficits in school-aged children with bronchopulmonary dysplasia (BPD).
Bronchopulmonary dysplasia (BPD) is the most common respiratory disease affecting children born prematurely and leads to long-term respiratory symptoms and lung function impairment throughout childhood. This study will, evaluate the contribution of indoor sources of respiratory irritants to respiratory health impairment in school-aged children with BPD. State-of-the-art measures of indoor air quality constituents will assess the relationship of nitrogen dioxide (NO2), particulate matter (PM2.5), as well as, concentrations of allergens (mold, mouse, cockroach, pet), endotoxin, air temperature and humidity with concurrently measured respiratory symptoms and lung function in a well-characterized cohort of children with BPD. This research will identify specific harmful components of the indoor environment associated with respiratory morbidity and poor lung function in children with BPD.
Investigators will ask the participants to come in for a one time clinic visit for undergoing procedures as well as answering questions regarding health and home environment. During the 1 year of participation there will also be 2 home assessment visits where investigators will take a sample of the home environment as well record home characteristics.
339 studies on the registry are indexed under Bronchopulmonary Dysplasia; 80 are open to participants now.
This study's enrollment of 165 is above the median of 137 across 92 observational studies indexed under Bronchopulmonary Dysplasia.
Browse Bronchopulmonary Dysplasia studies →Boston Children's Hospital is the lead sponsor of 598 studies on the registry; 151 are open to participants now.
Of its 31 completed or terminated interventional studies of FDA-regulated products, 18 (58%) have results posted.
Counted across the registry records on this site, refreshed daily.
Children 6-12 years with BPD in MA
Exclusion Criteria:
Respiratory Morbidity
maximum symptom days in the prior 2 weeks assessed at completion of home sampling visits ( Units: days scale: 0-14 days with symptoms, higher is worse
Time frame: 2 weeks
Lung Function
Spirometry (FEV1 percent predicted) Units: percent Scale: continuous integers, higher is better
Time frame: 1 yr
Lung function
Oscillometry (R5-20)
Time frame: 1 year
Lung function
Oscillometry (AX) units: cmH20 scale 0 - infinity, lower is better
Time frame: 1 year
Lung function
Oscillometry R5 units: cmH20 scale 0 - infinity, lower is better
Time frame: 1 year
Lung function
Oscillometry R5-20 units: cmH20 scale 0 - infinity, lower is better
Time frame: 1 year
Lung function
Oscillometry X5 units: cmH20 scale 0 - infinity, lower is better
Time frame: 1 year
Lung function
Oscillometry Fres units: Hz scale 0 - infinity, lower is better
Time frame: 1 year
Lung Function
FEV1/FVC units: percent scale: continuous integer, higher is better
Time frame: 1 year
Lung Function
FVC percent predicted units: percent scale: continuous integer, higher is better
Time frame: 1 year
Lung Function
FEF25-75 percent predicted units: percent scale: continuous integer, higher is better
Time frame: 1 year
Plan to share: No
This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Boston Children's Hospital