An interventional study of Supraglottic airway device and Standard airway management in Trauma Injury and Airway Control, sponsored by Jason Sperry. Completed at 14 sites in United States. Open to participants aged 15 Years and older. Per ClinicalTrials.gov, last updated 2026-04-14.
Sponsored by Jason Sperry · Not applicable, Interventional, and Treatment
The Prehospital Airway Control Trial (PACT) is a proposed 5 year, open label, multi-center, stepped-wedge randomized trial comparing airway management strategies of prehospital trauma patients. The initial airway attempt will be randomized to either usual care (control) or a supraglottic airway management approach (intervention). The primary outcome will be 24 hour survival, with secondary outcomes to include survival to hospital discharge, expected clinical adverse events, airway management performance, ICU length of stay, ventilator days, incidence of ARDS, and incidence of ventilator associated pneumonia. Subjects will be enrolled across approximately 17 prehospital agencies at select LITES Network sites and will enroll a total of 2,009 subjects.
128 studies on the registry are indexed under Accidental Injuries; 39 are open to participants now.
This study's enrollment of 2,010 is above the median of 110 across 67 interventional studies indexed under Accidental Injuries.
Browse Accidental Injuries studies →Jason Sperry is the lead sponsor of 10 studies on the registry; 3 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 3 (60%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Inclusion and exclusion criteria will be assessed based on information available at the time of enrollment, defined as the time at which enrolling agency provides positive pressure ventilation support. Although all reasonable efforts will be made by the emergency medical crew to either directly witness or obtain documentation of inclusion criteria, due to the nature of the emergency prehospital setting, there may be occasions where the emergency medical crew must rely on verbal report of inclusion criteria from referring hospital or emergency crew. In these instances, if, after subsequent review of outside hospital and/or ground crew documentation, it is determined that the subject did not meet inclusion criteria and/or met exclusion criteria, the subject will remain enrolled in the study based on the intention-to-treat principle.
If a verbal report must be used in lieu of physical documentation or directly witnessing inclusion criteria, documentation of the verbal report will serve as the source documentation for determining eligibility. Verbal reports will be documented in the emergency medical record and will detail the information provided and by whom.
Standard airway management strategy
Other: Standard airway management
Supraglottic first airway management strategy
Device: Supraglottic airway device
Initial advanced airway management with a supraglottic device
Also known as: LMA, King, igel
Initial advanced airway management with standard care method
24-hour survival
Time frame: From injury through 24 hours
Proportion of subjects that survive to hospital discharge
Time frame: From hospital admission through death or hospital discharge up to 30 days
Rate of first pass success of placement of advanced airway device
Time frame: At time of placement of device through confirmation of device placement
ICU length of stay
Time frame: Admission through 30 days or discharge
Ventilator days
Time frame: Admission through 30 days or discharge
Incidence of expected adverse events
Time frame: From initial airway management through first 24 hours of hospital admission
Incidence of need for rescue airway device
Time frame: At the time of placement of device through time of arrival to trauma bay
Incidence of hypoxia
Time frame: At the time of placement of device through time of arrival to trauma bay
Incidence of hypotension
Time frame: At the time of placement of device through time of arrival to trauma bay
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: No
Ran from Apr 2021 to primary completion in Mar 2026, 59 months.
Of 34 non-industry interventional studies with no phase under Accidental Injuries, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 51. This study's 59 months is above that.
Counting every sponsor, half of 35 studies reached it within 23 months; a quarter within 7 and three quarters within 41.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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Jason Sperry