CompletedNCT04081155PEEPUpdated Jul 14, 2020

Effect of PEEP on Lung Regional Ventilation and Perfusion

An observational study in Mechanical Ventilation Complication, Respiratory Failure and Hypoxia, sponsored by Yun Long. Completed at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-07-14.

Sponsored by Yun Long · Observational

Study type: Observational
Model: Case-only
Time perspective: Prospective
Enrollment: 33
Ages: 18 Years and older
Sex: All

Study summary

Investigate effects of PEEP on pulmonary regional ventilation and perfusion assessed by EIT

Read the detailed description

When the research team was available, adult patients within 7days who were sequentially admitted to the Department of Critical Care Medicine and required central venous catheters and mechanically ventilation were eligible for the study.
Written informed consent was obtained from all patients or next of kin before data were included in the study.
Information collected at enrollment included demographic characteristics, such as age, sex.
The blood pressure（BP）,heart rate（HR）, pulse O2（SpO2）,tidal volume and lung regional ventilation and perfusion were collected at PEEP 0 centimeter H2O column and PEEP 12-15 centimeter H2O column.
Indicator-based EIT method: rapidly inject 10ml 10% Sodium chloride（NaCL） through central venous catheter during a 8s respiratory hold, and the curve of impedence change was collected by EIT machine

Conditions studied

Mechanical Ventilation Complication
Respiratory Failure
Hypoxia

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Keywords

EIT
pulmonary perfusion
ventilation

In context

Respiratory Insufficiency

1,650 studies on the registry are indexed under Respiratory Insufficiency; 296 are open to participants now.

This study's enrollment of 33 is below the median of 100 across 545 observational studies indexed under Respiratory Insufficiency.

Browse Respiratory Insufficiency studies →

Lead sponsor

Yun Long is the lead sponsor of 3 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years and older
Sexes eligible: All
Accepts healthy volunteers: No
Sampling method: Probability sample

Study population

adult patients within 7 days, who were sequentially admitted to the Department of Critical Care Medicine and required central venous catheters and mechanically ventilation were eligible for the study

Inclusion criteria

have been placed central venous catheter based on patient's condition
Under mechanically ventilation
Under sedation and control ventilation mode
Year>18

Exclusion criteria

Exclusion Criteria:

Pneumothorax
pregnancy
Severe chest wall wound
Severe hypernatremia

Study design

Observational model: Case-only
Time perspective: Prospective
Enrollment: 33 participants (actual)
Patient registry: No

What researchers measure

Primary outcomes

lung regional ventilation distribution
lung regional ventilation distribution measured by EIT
Time frame: Hour 1
lung regional perfusion distribution
lung regional perfusion distribution measured by EIT
Time frame: Hour 1

Study locations

1 site

Peking Union Medical College Hospital, Chinese Academy of Medical Science
Beijing, Beijing, China

References and documents

Publications

He H, Chi Y, Long Y, Yuan S, Frerichs I, Moller K, Fu F, Zhao Z. Influence of overdistension/recruitment induced by high positive end-expiratory pressure on ventilation-perfusion matching assessed by electrical impedance tomography with saline bolus. Crit Care. 2020 Sep 29;24(1):586. doi: 10.1186/s13054-020-03301-x. PubMed 32993811 ↗

Individual participant data

Plan to share: Undecided

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Jul 14, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT04081155
Lead sponsor: Yun Long
Responsible party: Yun Long (the director of the intensive care medicine, Peking Union Medical College Hospital) — Sponsor-investigator
First posted: Sep 9, 2019
Start date: Jan 1, 2019
Primary completion: May 28, 2020
Completion: Jun 1, 2020
Last update: Jul 14, 2020

Study contacts

Yun Long

study chair · Peking Union Medical College Hospital

Oversight

Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2019. You cannot join it, but the record below documents what was studied.

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Discussion

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