An interventional study of Obesity-related genetic information disclosure with tailored lifestyle recommendations and Non-obesity-related genetic information disclosure in Weight Loss, sponsored by NaNa Keum. Completed at 1 site in South Korea. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-06.
Sponsored by NaNa Keum · Not applicable, Interventional, and Prevention
This trial aims to investigate whether tailored lifestyle consultation through SNP testing leads to more effective weight loss among overweight or obese individuals compared to general lifestyle guidance for weight control.
1,766 studies on the registry are indexed under Weight Loss; 277 are open to participants now.
This study's enrollment of 53 is below the median of 73 across 1,496 interventional studies indexed under Weight Loss.
Browse Weight Loss studies →This is the only study on the registry with NaNa Keum as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants received their obesity-related genetic test results, including variants in FTO (rs9939609), MC4R (rs17782313), and BDNF (rs6265), along with genotype-tailored lifestyle recommendations. The counseling materials encouraged risk-allele carriers to adopt healthier behaviors such as reducing fat intake, limiting snacking, and avoiding emotional eating. Personalized genetic results and recommendations were delivered at baseline through a user-friendly report.
Behavioral: Obesity-related genetic information disclosure with tailored lifestyle recommendations
Participants received genetic test results limited to non-obesity-related traits (e.g., beauty-related genes). They did not receive any obesity- or metabolism-related genetic information or tailored lifestyle recommendations. The full obesity-related genetic results were disclosed only after completion of the final follow-up.
Behavioral: Non-obesity-related genetic information disclosure
They received their complete SNP results, including obesity-related traits, along with corresponding lifestyle recommendations.
Provided only with genetic test results related to beauty traits at baseline; information on metabolic health-related SNPs was disclosed only after the final follow-up assessment.
Body Weight (kg)
Change was calculated as the value at the later time point minus the value at baseline (i.e., value at about 5 months after randomization minus baseline, and value at study completion (\~17 months) minus baseline). Positive values represent increases from baseline, and negative values represent decreases.
Time frame: About 5 months after randomization and at study completion (~17 months)
Body Fat Mass (kg)
Change was calculated as the value at the later time point minus the value at baseline (i.e., value at about 5 months after randomization minus baseline, and value at study completion (\~17 months) minus baseline). Positive values represent increases from baseline, and negative values represent decreases.
Time frame: About 5 months after randomization and at study completion (~17 months)
Body Fat Percentage (%)
Change was calculated as the value at the later time point minus the value at baseline (i.e., value at about 5 months after randomization minus baseline, and value at study completion (\~17 months) minus baseline). Positive values represent increases from baseline, and negative values represent decreases.
Time frame: About 5 months after randomization and at study completion (~17 months)
Skeletal Muscle Mass (kg)
Change was calculated as the value at the later time point minus the value at baseline (i.e., value at about 5 months after randomization minus baseline, and value at study completion (\~17 months) minus baseline). Positive values represent increases from baseline, and negative values represent decreases.
Time frame: About 5 months after randomization and at study completion (~17 months)
| Milestone | Experimental: Disclosure of Obesity-related Genetic Risk With Tailored Lifestyle Recommendations | Active Comparator: Disclosure of Non-Obesity-related Genetic Traits Only |
|---|---|---|
| Started | 27 | 26 |
| Completed | 20 | 21 |
| Not completed | 7 | 5 |
| Milestone | Experimental: Disclosure of Obesity-related Genetic Risk With Tailored Lifestyle Recommendations | Active Comparator: Disclosure of Non-Obesity-related Genetic Traits Only |
|---|---|---|
| Started | 20 | 21 |
| Completed | 8 | 10 |
| Not completed | 12 | 11 |
Change was calculated as the value at the later time point minus the value at baseline (i.e., value at about 5 months after randomization minus baseline, and value at study completion (\~17 months) minus baseline). Positive values represent increases from baseline, and negative values represent decreases.
| kg | Disclosure of obesity-related genetic risk with tailored lifestyle recommendations | Disclosure of non-obesity-related genetic traits only |
|---|---|---|
| About 5 months after randomization | 75.2 ± 13.2 | 79.2 ± 10.5 |
| About 17 months after randomization | 80.3 ± 19.4 | 74.5 ± 12.5 |
Change was calculated as the value at the later time point minus the value at baseline (i.e., value at about 5 months after randomization minus baseline, and value at study completion (\~17 months) minus baseline). Positive values represent increases from baseline, and negative values represent decreases.
| kg | Disclosure of obesity-related genetic risk with tailored lifestyle recommendations | Disclosure of non-obesity-related genetic traits only |
|---|---|---|
| About 5 months after randomization | 21.4 ± 10.2 | 23.7 ± 7.0 |
| About 17 months after randomization | 25.9 ± 12.3 | 23.8 ± 8.0 |
Change was calculated as the value at the later time point minus the value at baseline (i.e., value at about 5 months after randomization minus baseline, and value at study completion (\~17 months) minus baseline). Positive values represent increases from baseline, and negative values represent decreases.
| percentage | Disclosure of obesity-related genetic risk with tailored lifestyle recommendations | Disclosure of non-obesity-related genetic traits only |
|---|---|---|
| About 5 months after randomization | 28.5 ± 10.5 | 29.8 ± 7.8 |
| About 17 months after randomization | 31.8 ± 9.0 | 31.8 ± 8.4 |
Change was calculated as the value at the later time point minus the value at baseline (i.e., value at about 5 months after randomization minus baseline, and value at study completion (\~17 months) minus baseline). Positive values represent increases from baseline, and negative values represent decreases.
| kg | Disclosure of obesity-related genetic risk with tailored lifestyle recommendations | Disclosure of non-obesity-related genetic traits only |
|---|---|---|
| About 5 months after randomization | 30.1 ± 7.1 | 31.1 ± 5.6 |
| About 17 months after randomization | 30.4 ± 7.4 | 28.1 ± 5.9 |
Collected over No adverse events were observed from enrollment through study completion (up to ~17 months).. Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Disclosure of Obesity-related Genetic Risk With Tailored Lifestyle Recommendations | 0/27 (0%) | 0/27 (0%) | 0/27 (0%) |
| Disclosure of Non-Obesity-related Genetic Traits Only | 0/26 (0%) | 0/26 (0%) | 0/26 (0%) |
| Age, Categorical(Participants) | Experimental: Disclosure of Obesity-related Genetic Risk With Tailored Lifestyle Recommendations | Active Comparator: Disclosure of Non-Obesity-related Genetic Traits Only | Total |
|---|---|---|---|
| <=18 years | 0 | 0 | 0 |
| Between 18 and 65 years | 27 | 26 | 53 |
| >=65 years | 0 | 0 | 0 |
| Age, Continuous(years) | Experimental: Disclosure of Obesity-related Genetic Risk With Tailored Lifestyle Recommendations | Active Comparator: Disclosure of Non-Obesity-related Genetic Traits Only | Total |
|---|---|---|---|
| Mean | 22.22 ± 2.80 | 22.31 ± 3.07 | 22.26 ± 2.90 |
| Sex: Female, Male(Participants) | Experimental: Disclosure of Obesity-related Genetic Risk With Tailored Lifestyle Recommendations | Active Comparator: Disclosure of Non-Obesity-related Genetic Traits Only | Total |
|---|---|---|---|
| Female | 11 | 10 | 21 |
| Male | 16 | 16 | 32 |
| Race (NIH/OMB)(Participants) | Experimental: Disclosure of Obesity-related Genetic Risk With Tailored Lifestyle Recommendations | Active Comparator: Disclosure of Non-Obesity-related Genetic Traits Only | Total |
|---|---|---|---|
| American Indian or Alaska Native | 0 | 0 | 0 |
| Asian | 27 | 26 | 53 |
| Native Hawaiian or Other Pacific Islander | 0 | 0 | 0 |
| Black or African American | 0 | 0 | 0 |
| White | 0 | 0 | 0 |
| More than one race | 0 | 0 | 0 |
| Unknown or Not Reported | 0 | 0 | 0 |
| Region of Enrollment(participants) | Experimental: Disclosure of Obesity-related Genetic Risk With Tailored Lifestyle Recommendations | Active Comparator: Disclosure of Non-Obesity-related Genetic Traits Only | Total |
|---|---|---|---|
| South Korea | 27 | 26 | 53 |
| Body Weight (kg)(kg) | Experimental: Disclosure of Obesity-related Genetic Risk With Tailored Lifestyle Recommendations | Active Comparator: Disclosure of Non-Obesity-related Genetic Traits Only | Total |
|---|---|---|---|
| Mean | 74.3 ± 12.1 | 76.8 ± 11.2 | 75.6 ± 11.6 |
| Body fat mass (kg)(kg) | Experimental: Disclosure of Obesity-related Genetic Risk With Tailored Lifestyle Recommendations | Active Comparator: Disclosure of Non-Obesity-related Genetic Traits Only | Total |
|---|---|---|---|
| Mean | 21.1 ± 9.8 | 23.1 ± 6.8 | 22.1 ± 8.4 |
| Body fat percentage (%)(percentage) | Experimental: Disclosure of Obesity-related Genetic Risk With Tailored Lifestyle Recommendations | Active Comparator: Disclosure of Non-Obesity-related Genetic Traits Only | Total |
|---|---|---|---|
| Mean | 28.3 ± 10.7 | 31.1 ± 7.7 | 29.2 ± 9.3 |
1 further baseline measures are reported on the registry.
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