An interventional study of Oxygen application and Sham room air in Grown-up Congenital Heart Disease (GUCH), sponsored by University of Zurich. Completed at 1 site in Switzerland. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2021-04-19.
Sponsored by University of Zurich · Not applicable, Interventional, and Supportive care
In a randomized, sham-controlled crossover trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with grown-up congenital heart disease.
3,639 studies on the registry are indexed under Heart Diseases; 461 are open to participants now.
This study's enrollment of 7 is below the median of 100 across 1,778 interventional studies indexed under Heart Diseases.
Browse Heart Diseases studies →University of Zurich is the lead sponsor of 1,030 studies on the registry; 130 are open to participants now.
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Exclusion Criteria:
Supplemental oxygen will be applied via a mask during CPET
Procedure: Oxygen application
Room air will be applied similarly to oxygen
Procedure: Sham room air
Oxygen application Supplemental oxygen via mask
Room air applied via mask
Work Rate (Watt)
Maximal Work Rate (Wmax) measured during cardiopulmonary exercise test oxygen vs. room air
Time frame: 1 day
Endurance Time (s) Endurance Time (s) Endurance Time (s)
Endurance (s) with 75% Wmax measured during cardiopulmonary exercise test oxygen vs. room air
Time frame: 1 day
Peak Oxygen uptake
measured during cardiopulmonary exercise test oxygen vs. room air
Time frame: 1 day
Respiratory Exchange ratio
measured during cardiopulmonary exercise test oxygen vs. room air
Time frame: 1 day
Changes in arterial blood parameters
measured during cardiopulmonary exercise test oxygen vs. room air
Time frame: 1 day
muscle tissue oxygen
Oxygen saturation in the muscle measured during cardiopulmonary exercise test oxygen vs. room air with near infrared spectroscopy
Time frame: 1 day
cerebral tissue oxygen
Oxygen saturation in the brain measured during cardiopulmonary exercise test oxygen vs. room air with near infrared spectroscopy
Time frame: 1 day
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Apr 2021. You cannot join it, but the record below documents what was studied.
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University of Zurich