An observational study in Sepsis, sponsored by Jianfeng Xie. Completed at 1 site in China. Per ClinicalTrials.gov, last updated 2019-07-26.
Sponsored by Jianfeng Xie · Observational
Sepsis is a common critical illness in Intensive Care Unit (ICU). With the continuous progress of severe medicine, the mortality rate of ICU hospitalization for sepsis has decreased, but the long-term prognosis is not satisfied. Due to the high long-term mortality, poor physical and mental health and cognitive impairment, the long-term quality of life decreases greatly, putting great burden on the family and society. Therefore, it is of great significance to understand the epidemiology and risk factors of the long-term prognosis of sepsis and find out how to improve the prognosis .
Sepsis is a clinical syndrome in which the body's host response to uncontrolled infection leads to life-threatening organ dysfunction. In recent years, with the continuous improvement of the early diagnosis ability of sepsis, the deepening of the understanding of pathophysiology, and the continuous updating of treatment, the hospital mortality rate of sepsis has decreased significantly. However, studies have shown that the prevalence of sepsis is still increasing year by year, and the number of deaths due to sepsis is increasing. Sepsis is the main cause of death in ICU patients.
Although the mortality rate of patients with sepsis is significantly reduced, the increasing survival of patients with long-term outcome is not satisfied. All studies have shown that patients with sepsis have a high long-term mortality, and the long-term physiological, psychological, and cognitive function levels are reduced, which increases the economic burden and mental burden of the family and society. The increasing number of discharges has been considered a potential public health threat. In recent years, more and more researchers begin to pay attention to the long-term outcome of sepsis survivors. But compared with other acute or severe diseases, such as stroke, cancer, sepsis survivors has not been paid enough attention.
Therefore, all stages of treatment and rehabilitation of sepsis require extensive social attention. Continuous research and input are needed to explore predicting factors and effective interventions to improve the outcome and help patients and their families return to normal life,to reduce the social burden.
1,946 studies on the registry are indexed under Sepsis; 471 are open to participants now.
This study's enrollment of 1,368 is above the median of 160 across 957 observational studies indexed under Sepsis.
Browse Sepsis studies →Jianfeng Xie is the lead sponsor of 13 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
sepsis patients survived 90 days of oneset
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
2-year mortality
sepsis survivors will be followed up for 2-years
Time frame: 2 year
2-year readmission rate
sepsis survivors will be followed up for 2-years
Time frame: 2 year
mobility of sepsis survivors
one dimension of EQ-5D, which includes five dimensions and is used to evaluate the quaity of life of sepsis survivors. They are mobility， self-care，usual activities，discomfort or pain and depression or anxiety.
Time frame: 2 year
self-care of sepsis survivors
one dimension of EQ-5D, which includes five dimensions and is used to evaluate the quaity of life of sepsis survivors. They are mobility， self-care，usual activities，discomfort or pain and depression or anxiety.
Time frame: 2 year
usual activities of sepsis survivors
one dimension of EQ-5D, which includes five dimensions and is used to evaluate the quaity of life of sepsis survivors. They are mobility， self-care，usual activities，discomfort or pain and depression or anxiety.
Time frame: 2 year
discomfort or pain of sepsis survivors
one dimension of EQ-5D, which includes five dimensions and is used to evaluate the quaity of life of sepsis survivors. They are mobility， self-care，usual activities，discomfort or pain and depression or anxiety.
Time frame: 2 year
depression or anxiety of sepsis survivors
one dimension of EQ-5D, which includes five dimensions and is used to evaluate the quaity of life of sepsis survivors. They are mobility， self-care，usual activities，discomfort or pain and depression or anxiety.
Time frame: 2 year
the ability to judge and memory of sepsis survivors
It is scored by family or by yourself during telephone follow-up and is used to evaluate the quaity of life of sepsis survivors.
Time frame: 2 year
influencing factors
explore the relationship between the outcome of sepsis survivors and clinical characteristics.The clinical characteristics is collected from Clinical case system,to explore their relationship with two-year survival, two-year quality of life of sepsis survivors.
Time frame: 2 year
Ran from Nov 2015 to primary completion in Aug 2018, 33 months.
Of 408 non-industry observational studies under Sepsis, half reached primary completion within 30 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 60. This study's 33 months is close to that.
Counting every sponsor, half of 452 studies reached it within 29 months; a quarter within 12 and three quarters within 57.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jul 2019. You cannot join it, but the record below documents what was studied.
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Jianfeng Xie