A Phase 2/3 interventional study of Autologous Platelet Rich Plasma (PRP) intra ovarian infusion and Placebo: Autologous Platelet Free Plasma (PFP) intra ovarian infusion in Infertility, Female, Perimenopausal Disorder and Menstrual Cycle Abnormal, sponsored by Genesis Athens Clinic. Recruiting at 1 site in Greece. Open to female participants aged 40 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-08.
Sponsored by Genesis Athens Clinic · Phase 2/3, Interventional, and Treatment
Autologous PRP intra ovarian infusion may improve ovarian response and women's hormonal profile and may promote folliculogenesis in perimenopausal women.
This triple-blind Randomized Controlled Trial (RCT) aims to investigate the effectiveness of autologous PRP intra ovarian infusion on improving ovarian tissue functionality and hormonal profile of perimenopausal women. PRP is blood plasma prepared from fresh whole blood that has been enriched with platelets. It is collected from peripheral veins and contains several growth factors such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), platelet derived growth factor (PDGF), transforming growth factor (TGF) and other cytokines all of which stimulate tissue proliferation and growth. PRP has been employed in several medical conditions in Orthopedics, Dermatology, and Ophthalmology for wound healing. It's efficacy in ovarian rejuvenation and reactivation and endometrial regeneration has not been fully elucidated. This study aims to investigate the effect of autologous PRP intra ovarian infusion on improving ovarian tissue functionality in perimenopausal women.
Exclusion Criteria:
Perimenopausal women, 40-50 years of age, treated with autologous PRP intra ovarian infusion.
Biological: Autologous Platelet Rich Plasma (PRP) intra ovarian infusion
Perimenopausal women, 40-50 years of age, treated with autologous PRP intra ovarian infusion.
Other: Placebo: Autologous Platelet Free Plasma (PFP) intra ovarian infusion
Autologous PRP intra ovarian infusion
Also known as: PRP, Platelet Rich Plasma
Autologous PFP intra ovarian infusion
Also known as: PFP, Platelet Free Plasma
Restoration of menstrual cycle regularity
Regular Menstrual cycle
Time frame: Three months
Serum FSH levels
Serum FSH levels evaluated monthly for three consecutive months.
Time frame: Follow-up period of three months entailing monthly evaluation
Serum AMH levels
Serum AMH levels evaluated monthly for three consecutive months.
Time frame: Follow-up period of three months entailing monthly evaluation
Serum LH levels
Serum LH levels evaluated monthly for three consecutive months.
Time frame: Follow-up period of three months entailing monthly evaluation
Serum Estradiol levels
Serum etsradiol levels evaluated monthly for three consecutive months.
Time frame: Follow-up period of three months entailing monthly evaluation
Serum Progesteron levels
Serum progesterone levels evaluated monthly for three consecutive months.
Time frame: Follow-up period of three months entailing monthly evaluation
Antral Follicle Count
AFC evaluated monthly, on day 2 of the menstrual cycle, for three consecutive months.
Time frame: Follow-up period of three months entailing monthly evaluation
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Genesis Athens Clinic