A Phase 2/3 interventional study of Autologous Platelet Rich Plasma (PRP) intra ovarian infusion and Placebo: Autologous Platelet Free Plasma (PFP) intra ovarian infusion in Infertility, Female, Perimenopausal Disorder and Menstrual Cycle Abnormal, sponsored by Genesis Athens Clinic. Recruiting at 1 site in Greece. Open to female participants aged 40 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-08.
Sponsored by Genesis Athens Clinic · Phase 2/3, Interventional, and Treatment
Autologous PRP intra ovarian infusion may improve ovarian response and women's hormonal profile and may promote folliculogenesis in perimenopausal women.
This triple-blind Randomized Controlled Trial (RCT) aims to investigate the effectiveness of autologous PRP intra ovarian infusion on improving ovarian tissue functionality and hormonal profile of perimenopausal women. PRP is blood plasma prepared from fresh whole blood that has been enriched with platelets. It is collected from peripheral veins and contains several growth factors such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), platelet derived growth factor (PDGF), transforming growth factor (TGF) and other cytokines all of which stimulate tissue proliferation and growth. PRP has been employed in several medical conditions in Orthopedics, Dermatology, and Ophthalmology for wound healing. It's efficacy in ovarian rejuvenation and reactivation and endometrial regeneration has not been fully elucidated. This study aims to investigate the effect of autologous PRP intra ovarian infusion on improving ovarian tissue functionality in perimenopausal women.
552 studies on the registry are indexed under Infertility, Female; 137 are open to participants now.
This study's planned enrollment of 100 is close to the median of 100 across 378 interventional studies indexed under Infertility, Female.
Browse Infertility, Female studies →Genesis Athens Clinic is the lead sponsor of 7 studies on the registry; 5 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Neoadjuvant treatment is given before the main treatment (usually surgery), often to shrink a tumour. Adjuvant treatment is given after it, to lower the chance of the cancer coming back.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Adjuvant and neoadjuvant
Neoadjuvant treatment is given before the main treatment (usually surgery), often to shrink a tumour. Adjuvant treatment is given after it, to lower the chance of the cancer coming back.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Autoimmune disease
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Perimenopausal women, 40-50 years of age, treated with autologous PRP intra ovarian infusion.
Biological: Autologous Platelet Rich Plasma (PRP) intra ovarian infusion
Perimenopausal women, 40-50 years of age, treated with autologous PRP intra ovarian infusion.
Other: Placebo: Autologous Platelet Free Plasma (PFP) intra ovarian infusion
Autologous PRP intra ovarian infusion
Also known as: PRP, Platelet Rich Plasma
Autologous PFP intra ovarian infusion
Also known as: PFP, Platelet Free Plasma
Restoration of menstrual cycle regularity
Regular Menstrual cycle
Time frame: Three months
Serum FSH levels
Serum FSH levels evaluated monthly for three consecutive months.
Time frame: Follow-up period of three months entailing monthly evaluation
Serum AMH levels
Serum AMH levels evaluated monthly for three consecutive months.
Time frame: Follow-up period of three months entailing monthly evaluation
Serum LH levels
Serum LH levels evaluated monthly for three consecutive months.
Time frame: Follow-up period of three months entailing monthly evaluation
Serum Estradiol levels
Serum etsradiol levels evaluated monthly for three consecutive months.
Time frame: Follow-up period of three months entailing monthly evaluation
Serum Progesteron levels
Serum progesterone levels evaluated monthly for three consecutive months.
Time frame: Follow-up period of three months entailing monthly evaluation
Antral Follicle Count
AFC evaluated monthly, on day 2 of the menstrual cycle, for three consecutive months.
Time frame: Follow-up period of three months entailing monthly evaluation
Started Jun 2019 (actual). Primary completion is estimated for Jan 2027, 91 months after the start.
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Studies of the drug tested here: Platelet rich plasma
Genesis Athens Clinic