An interventional study of Thoracic epidural and Paravertebral block in Lung Cancer and Postoperative Pain, sponsored by St. Olavs Hospital. Completed at 1 site in Norway. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2024-01-03.
Sponsored by St. Olavs Hospital · Not applicable, Interventional, and Treatment
Thoracic epidural analgesia (TEA) is the basic method of analgesia in patients undergoing pulmonary lobectomy. TEA is considered to be a safe and thoroughly investigated method of pain relief that rarely causes serious complications. However, blocking the nerves as they emerge from the spinal column (paravertebral block, PVB) may represent an alternative method with some potential benefits. In this study, TEA and PVB will be compared for patients undergoing pulmonary lobectomy by video assisted thoracoscopic surgery. The aim of the study is to test the hypothesis, that PVB is a time-saving procedure compared with TEA on the day of surgery and that PVB is as efficient in postoperative pain reduction as TEA.
5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.
This study's enrollment of 94 is above the median of 75 across 4,344 interventional studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →St. Olavs Hospital is the lead sponsor of 165 studies on the registry; 30 are open to participants now.
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Inclusion Criteria:
Patients with lung cancer in stage 1 or 2 who are accepted for VATS-lobectomy
Exclusion Criteria, preoperative:
Patients who do not wish to participate
Patients with:
Exclusion Criteria, Per- and postoperative
Patients who wish to withdraw from the study
Standard thoracic epidurals preoperatively at the dag of surgery.
Drug: Thoracic epidural
Paravertebral block inserted at the end of the operation by the surgeons
Drug: Paravertebral block
Standard thoracic epidural (needle inserted into the space between the covering of spinal cord and the cord itself) preoperatively. Standard thoracic epidural analgesia mixture (2 mg/ ml bupivacaine, 2 µg/ ml fentanyl and 2 µg/ ml adrenalin) with an infusion of 6-10 ml/hour until day 2 postoperatively. Thereafter reduction by 30 % every four hours.
Paravertebral block containing 5 ml bupivacaine 5 mg/ ml (optionally 10 ml bupivacaine 2,5 mg/ ml). In addition per-oral painkillers (oxycodone and paracetamol) from the day of surgery.
Time in minutes total time at the operating ward
Time frame: 1 hour
Pain intensity during hospitalization: Numerical Rating Scale (NRS)
using the Numerical Rating Scale (NRS) in predetermined time intervals after the operation
Time frame: Up to 12 months after surgery
Hospital length of stay in days
Time frame: until discharge from hospital (max 1 month)
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Dec 2023. You cannot join it, but the record below documents what was studied.
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