An interventional study of B-FREE in Knee Injuries, Knee Osteoarthritis and Knee Arthritis, sponsored by Michigan Technological University. Active, not recruiting at 1 site in United States. Open to participants aged 40 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-15.
Sponsored by Michigan Technological University · Not applicable, Interventional, and Treatment
This study will determine the safety and efficacy of using blood-flow restriction exercise enhancement (B-FREE) to overcome persistent quadriceps muscle weakness that occurs following a total knee replacement (TKR).
This study aims to determine the safety and efficacy of using B-FREE to overcome persistent quadriceps muscle weakness that occurs following a TKR. We hypothesize that B-FREE can provide a safe training stimulus and offer a home-based program to restore quadriceps muscle strength and improve functional mobility. Specifically, subjects that have a TKR will perform B-FREE at home (light weights with resistance bands and walking) 3x/wk for 10 weeks. Quadriceps muscle strength, balance, and functional mobility will be assessed before and after the program. Changes in these variables will be compared to healthy age-matched uninjured controls.
249 studies on the registry are indexed under Knee Injuries; 48 are open to participants now.
This study's planned enrollment of 30 is below the median of 50 across 160 interventional studies indexed under Knee Injuries.
Browse Knee Injuries studies →Michigan Technological University is the lead sponsor of 5 studies on the registry; none are open to participants now.
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Exclusion Criteria
Participants that have a total knee replacement will complete a home-based exercise program
Other: B-FREE
Participants that have no history of knee joint dysfunction will serve as age-matched uninjured controls
Blood flow-restriction exercise enhancement (B-FREE) will be performed at home 3x/wk for 10 weeks. A blood pressure cuff will be inflated to partially occlude blood to the limb during light weight exercises involving knee extension, body weight squats, and walking.
Change in Muscle size
quadriceps muscle thickness
Time frame: Change from baseline at 10 weeks
Change in Muscle strength
quadriceps muscle strength
Time frame: Change from baseline at 10 weeks
Change in Walking performance
walking distance
Time frame: Change from baseline at 10 weeks
Change in Balance
balance assessment
Time frame: Change from baseline at 10 weeks
Plan to share: No
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Michigan Technological University