An interventional study of Clinical and biological assessments - a 5 Years follow-up in Borderline Personality Disorder, sponsored by University Hospital, Montpellier. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-09-30.
Sponsored by University Hospital, Montpellier · Not applicable, Interventional, and Other
Borderline Personality Disorder (BPD) is a common psychiatric disorder occurring in 2 to 6% of the population. 70% of patients with BPD do at least one Suicide Attempt (SA) in their lives. It makes BPD the most related to SA condition.
Negative interpersonal events are among the main stressor inducing a SA. Patients with BPD are characterized by emotional dysregulation, impulsivity (repeated parasuicidal and suicidal behaviors), and instability in interpersonal relationships. The feeling of shame related to this psychiatric disorder could be one of the causes of the high SA rate. In this study, patients with BPD will be follow-up during 5 years.
The main objective is to study the propensity to feel shame as a predictor of SA.
This include:
This is a 5 years follow-up prospective study recruiting 688 patients.
Schedule of the study :
Inclusion period : 3 years Duration of follow-up of each patient : 5 years Estimated duration of the study : 8.5 years
As part of the research, patients will be summoned annually for 5 years.
The first visit (at baseline) is included in the usual care
The follow-up visits are specifics to the research
During the visits patients will complete self questionary and clinical interview.
The organization of visits is as follows:
Genetic samples will be taken during the initial visit as well as during the visit to 5 years.
They consist of:
269 studies on the registry are indexed under Borderline Personality Disorder; 67 are open to participants now.
This study's planned enrollment of 688 is above the median of 70 across 215 interventional studies indexed under Borderline Personality Disorder.
Browse Borderline Personality Disorder studies →University Hospital, Montpellier is the lead sponsor of 1,244 studies on the registry; 225 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion criteria:
Exclusion criteria:
At each visit, these patients will have an interview that will allow for a clinical evaluation, as well as completing the hetero-questionnaires and self-questionnaires
Other: Clinical and biological assessments - a 5 Years follow-up
During each visit, a clinical evaluation will be carried out, as well as the filling of hetero-questionnaires and self-questionnaires. Two biological collections will be made: one during the inclusion visit, and the other during the last visit, 5 years after inclusion.
Level of shame propensity
Evaluation of the level of shame propensity will be measured using the Test of Self Conscious Affect (TOSCA)
Time frame: At enrollment
Level of shame propensity
Evaluation of the level of shame propensity will be measured using the Test of Self Conscious Affect (TOSCA)
Time frame: 1 year after enrollment
Level of shame propensity
Evaluation of the level of shame propensity will be measured using the Test of Self Conscious Affect (TOSCA)
Time frame: 2 years after enrollment
Level of shame propensity
Evaluation of the level of shame propensity will be measured using the Test of Self Conscious Affect (TOSCA)
Time frame: 3 years after enrollment
Level of shame propensity
Evaluation of the level of shame propensity will be measured using the Test of Self Conscious Affect (TOSCA)
Time frame: 4 years after enrollment
Level of shame propensity
Evaluation of the level of shame propensity will be measured using the Test of Self Conscious Affect (TOSCA)
Time frame: 5 years after enrollment
Number of SA compared to the clinical data obtained in baseline
The number of SA will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the clinical data obtained in baseline
Time frame: At enrollment
Number of SA compared to the clinical data obtained in baseline
The number of SA within the year will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the clinical data obtained in baseline
Time frame: 1 year after enrollment
Number of SA compared to the clinical data obtained in baseline
The number of SA within the year will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the clinical data obtained in baseline
Time frame: 2 years after enrollment
Number of SA compared to the clinical data obtained in baseline
The number of SA within the year will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the clinical data obtained in baseline
Time frame: 3 years after enrollment
Number of SA compared to the clinical data obtained in baseline
The number of SA within the year will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the clinical data obtained in baseline
Time frame: 4 years after enrollment
Number of SA compared to the clinical data obtained in baseline
The number of SA within the year will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the clinical data obtained in baseline
Time frame: 5 years after enrollment
Number of SA compared to the biological data obtained in baseline
The number of SA will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the biological data obtained in baseline
Time frame: At enrollment
Number of SA compared to the biological data obtained in baseline
The number of SA will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the biological data obtained in baseline
Time frame: 1 year after enrollment
Number of SA compared to the biological data obtained in baseline
The number of SA will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the biological data obtained in baseline
Time frame: 2 years after enrollment
Number of SA compared to the biological data obtained in baseline
The number of SA will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the biological data obtained in baseline
Time frame: 3 years after enrollment
Number of SA compared to the biological data obtained in baseline
The number of SA within the year will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the biological data obtained in baseline
Time frame: 4 years after enrollment
Number of SA compared to the biological data obtained in baseline
The number of SA within the year will be collected using Columbia Suicide Severity Rating Scale (C-SSRS) and compared to the biological data obtained in baseline
Time frame: 5 years after enrollment
Suicidal Ideation
The number of suicidal ideation will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: At enrollment
Suicidal Ideation
The number of suicidal ideation will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 1 year after enrollment
Suicidal Ideation
The number of suicidal ideation will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 2 years after enrollment
Suicidal Ideation
The number of suicidal ideation will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 3 years after enrollment
Suicidal Ideation
The number of suicidal ideation will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 4 years after enrollment
Suicidal Ideation
The number of suicidal ideation will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 5 years after enrollment
Parasuicidal Behaviours
The number of parasuicidal behaviours will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: At enrollment
Parasuicidal Behaviours
The number of parasuicidal behaviours will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 1 year after enrollment
Parasuicidal Behaviours
The number of parasuicidal behaviours will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 2 years after enrollment
Parasuicidal Behaviours
The number of parasuicidal behaviours will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 3 years after enrollment
Parasuicidal Behaviours
The number of parasuicidal behaviours will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 4 years after enrollment
Parasuicidal Behaviours
The number of parasuicidal behaviours will be collected using Columbia Suicide Severity Rating Scale (C-SSRS).
Time frame: 5 years after enrollment
Sick leave for a psychiatric condition
The number of sick leaves, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: At enrollment
Sick leave for a psychiatric condition
The number of sick leaves, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 1 year after enrollment
Sick leave for a psychiatric condition
The number of sick leaves, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 2 years after enrollment
Sick leave for a psychiatric condition
The number of sick leaves, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 3 years after enrollment
Sick leave for a psychiatric condition
The number of sick leaves, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 4 years after enrollment
Sick leave for a psychiatric condition
The number of sick leaves, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 5 years after enrollment
Hospitalization for a psychiatric condition
The number of hospitalization, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: At enrollment
Hospitalization for a psychiatric condition
The number of hospitalization, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 1 year after enrollment
Hospitalization for a psychiatric condition
The number of hospitalization, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 2 years after enrollment
Hospitalization for a psychiatric condition
The number of hospitalization, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 3 years after enrollment
Hospitalization for a psychiatric condition
The number of hospitalization, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 4 years after enrollment
Hospitalization for a psychiatric condition
The number of hospitalization, related to BPD, and their duration will be collected and reported on the case report form (CRF).
Time frame: 5 years after enrollment
The need to emergency psychiatric consult
The number of emergency visit related to BPD, will be collected and reported on the case report form (CRF).
Time frame: At enrollment
The need to emergency psychiatric consult
The number of emergency visit related to BPD, will be collected and reported on the case report form (CRF).
Time frame: 1 year after enrollment
The need to emergency psychiatric consult
The number of emergency visit related to BPD, will be collected and reported on the case report form (CRF).
Time frame: 2 years after enrollment
The need to emergency psychiatric consult
The number of emergency visit related to BPD, will be collected and reported on the case report form (CRF).
Time frame: 3 years after enrollment
The need to emergency psychiatric consult
The number of emergency visit related to BPD, will be collected and reported on the case report form (CRF).
Time frame: 4 years after enrollment
The need to emergency psychiatric consult
The number of emergency visit related to BPD, will be collected and reported on the case report form (CRF).
Time frame: 5 years after enrollment
Major depressive episodes
The number of major depressives episodes and the measure of the depression intensity will be collected using the Inventory of Depressive Symptomatology (IDS-C30).
Time frame: At enrollment
Major depressive episodes
The number of major depressives episodes and the measure of the depression intensity will be collected using the Inventory of Depressive Symptomatology (IDS-C30).
Time frame: 1 year after enrollment
Major depressive episodes
The number of major depressives episodes and the measure of the depression intensity will be collected using the Inventory of Depressive Symptomatology (IDS-C30).
Time frame: 2 years after enrollment
Major depressive episodes
The number of major depressives episodes and the measure of the depression intensity will be collected using the Inventory of Depressive Symptomatology (IDS-C30).
Time frame: 3 years after enrollment
Major depressive episodes
The number of major depressives episodes and the measure of the depression intensity will be collected using the Inventory of Depressive Symptomatology (IDS-C30).
Time frame: 4 years after enrollment
Major depressive episodes
The number of major depressives episodes and the measure of the depression intensity will be collected using the Inventory of Depressive Symptomatology (IDS-C30).
Time frame: 5 years after enrollment
Global functioning
The Global functioning will be measured using the Functioning Assessment Short Test (FAST).
Time frame: At enrollment
Global functioning
The Global functioning will be measured using the Functioning Assessment Short Test (FAST).
Time frame: 1 year after enrollment
Global functioning
The Global functioning will be measured using the Functioning Assessment Short Test (FAST).
Time frame: 2 years after enrollment
Global functioning
The Global functioning will be measured using the Functioning Assessment Short Test (FAST).
Time frame: 3 years after enrollment
Global functioning
The Global functioning will be measured using the Functioning Assessment Short Test (FAST).
Time frame: 4 years after enrollment
Global functioning
The Global functioning will be measured using the Functioning Assessment Short Test (FAST).
Time frame: 5 years after enrollment
Life Quality
The Life Quality will be measured using the Satisfaction With Life Scale (SWLS).
Time frame: At enrollment
Life Quality
The Life Quality will be measured using the Satisfaction With Life Scale (SWLS).
Time frame: 1 year after enrollment
Life Quality
The Life Quality will be measured using the Satisfaction With Life Scale (SWLS).
Time frame: 2 years after enrollment
Life Quality
The Life Quality will be measured using the Satisfaction With Life Scale (SWLS).
Time frame: 3 years after enrollment
Life Quality
The Life Quality will be measured using the Satisfaction With Life Scale (SWLS).
Time frame: 4 years after enrollment
Life Quality
The Life Quality will be measured using the Satisfaction With Life Scale (SWLS).
Time frame: 5 years after enrollment
Plan to share: No
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Borderline Personality Disorder→
University Hospital, Montpellier