An interventional study of Strategy-Based Training to Enhance Memory (STEM) and Placebo control exercises in Multiple Sclerosis, sponsored by Kessler Foundation. Completed at 2 sites in United States. Open to participants aged 18 Years to 59 Years. Per ClinicalTrials.gov, last updated 2026-07-22.
Sponsored by Kessler Foundation · Not applicable, Interventional, and Treatment
The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in persons with Multiple Sclerosis.
The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in persons with Multiple Sclerosis (MS). The study is designed to research how well this technique can help people with MS improve their memory and their ability to function better in everyday life.
3,460 studies on the registry are indexed under Multiple Sclerosis; 661 are open to participants now.
This study's enrollment of 81 is above the median of 50 across 2,342 interventional studies indexed under Multiple Sclerosis.
Browse Multiple Sclerosis studies →Kessler Foundation is the lead sponsor of 170 studies on the registry; 58 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
For Optional MRI:
The experimental group will receive memory enhancement exercises administered twice a week for 4 weeks (8 training sessions).
Behavioral: Strategy-Based Training to Enhance Memory (STEM)
The control group will receive placebo memory enhancement exercises administered twice a week for 4 weeks (8 training sessions).
Behavioral: Placebo control exercises
Protocol designed to improve memory functioning in individuals with neurological injuries administered for 4 weeks (8 training sessions).
Placebo control memory exercises will be administered for 4 weeks (8 training sessions).
Changes in scores on self-report measure of everyday cognition (subjective)
Perceived Deficits Questionnaire
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in scores on self-report measure of everyday cognition (objective)
Ecologic Memory Simulations
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in auditory processing speed
Paced Auditory Serial Edition Test
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in information processing speed
Symbol Digit Modalities Test
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in episodic verbal memory and learning
California Verbal Learning Test - 2nd Edition
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in visuospatial memory
Brief Visuospatial Memory Test - Revised
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in ability in spontaneous production of words
Controlled Oral Word Association Test
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in visual perception
Benton Judgment of Line Orientation
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in executive function
Delis-Kaplan Executive Function System - Sorting
Time frame: Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Kessler Foundation