An interventional study of Ready-made pancakes enriched with docosahexaenoic acid (DHA) and Ready-made pancakes enriched with beta-glucan (BG) in Metabolic Syndrome, sponsored by University of Leeds. Completed at 1 site in United Kingdom. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-05-20.
Sponsored by University of Leeds · Not applicable, Interventional, and Basic science
This pilot study will investigate the enrichment type, in pancakes, most effective at improving markers of metabolic syndrome. Ready-made pancakes enriched with either docosahexaenoic acid (DHA), beta-glucan (BG) or anthocyanins (AC), alone or in combination of DHA+BG or DHA+AC, will be consumed for 4 weeks.
There is scientific evidence to support health claims that docosahexaenoic acid (DHA), an omega-3 fatty acid, and beta-glucan (BG), a soluble plant fibre, can help to maintain healthy cholesterol and triglyceride levels. It is also reported that anthocyanins (AC), colour pigments found in many dietary plants, can lower concentrations of low-density lipoprotein (LDL) cholesterol and increase high-density lipoprotein (HDL) cholesterol in dyslipidemic adults. Research studies often focus on bioactives administered as supplements, this study will also investigate the effectiveness of the food matrix. The project addresses the exploitation of bioactive compounds extracted from natural food sources that when added as ingredients to foods and consumed within the common diet, could significantly benefit human health and wellbeing.
1,964 studies on the registry are indexed under Metabolic Syndrome; 330 are open to participants now.
This study's enrollment of 35 is below the median of 60 across 1,460 interventional studies indexed under Metabolic Syndrome.
Browse Metabolic Syndrome studies →University of Leeds is the lead sponsor of 200 studies on the registry; 25 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Subjects will be eligible to the pilot study if they present with two to four of the criteria for metabolic syndrome (MetS), at least one of them being alteration of fasting triglycerides or HDL-C cholesterol. MetS is defined when three of the following criteria are met:
Exclusion Criteria:
Participants are excluded if three or more clinical criteria for metabolic syndrome are met. Additionally, major exclusion criteria are:
One portion of pancakes enriched with 250 mg docosahexaenoic acid (DHA) to be consumed daily for 4 weeks.
Dietary Supplement: Ready-made pancakes enriched with docosahexaenoic acid (DHA)
One portion of pancakes enriched with 3 g beta-glucan (BG) to be consumed daily for 4 weeks.
Dietary Supplement: Ready-made pancakes enriched with beta-glucan (BG)
One portion of pancakes enriched with 320 mg anthocyanins (AC) to be consumed daily for 4 weeks.
Dietary Supplement: Ready-made pancakes enriched with anthocyanins (AC)
One portion of pancakes enriched with 250 mg docosahexaenoic acid (DHA) plus 3 g beta-glucan (BG) to be consumed daily for 4 weeks.
Dietary Supplement: Ready-made pancakes enriched with docosahexaenoic acid and beta-glucan (DHA+BG)
One portion of pancakes enriched with 250 mg docosahexaenoic acid (DHA) plus 320 mg anthocyanins (AC) to be consumed daily for 4 weeks.
Dietary Supplement: Ready-made pancakes enriched with docosahexaenoic acid and anthocyanins (DHA+AC)
One portion of DHA-enriched pancakes will be eaten each day for 4 weeks.
One portion of BG-enriched pancakes will be eaten each day for 4 weeks.
One portion of AC-enriched pancakes will be eaten each day for 4 weeks.
One portion of DHA+BG-enriched pancakes will be eaten each day for 4 weeks.
One portion of DHA+AC-enriched pancakes will be eaten each day for 4 weeks.
Fasting triglyceride concentration
Change in fasting triglyceride concentration between baseline and endpoint
Time frame: Day 1 to Day 28
Fasting HDL concentration
Change in fasting HDL concentration between baseline and endpoint
Time frame: Day 1 to Day 28
Blood pressure
Change in systolic and/or diastolic blood pressure between baseline and endpoint
Time frame: Day 1 to day 28
Fasting blood glucose concentration
Change in fasting blood glucose concentration between baseline and endpoint
Time frame: Day 1 to day 28
Waist circumference
Change in waist circumference between baseline and endpoint
Time frame: Day 1 to day 28
Body mass index
Change in body mass index between baseline and endpoint
Time frame: Day 1 to day 28
Plan to share: No
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This study is completed, as verified in May 2019. You cannot join it, but the record below documents what was studied.
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University of Leeds