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TerminatedNCT03952182Updated Mar 24, 2022

Effect of Bracing Versus No Bracing in Stable Thoracolumbar Compression and Burst Fractures

An interventional study of Spinal Orthosis (LSO, TLSO) and No orthosis in Thoracic Fracture, Lumbar Fracture and Compression Fracture of Thoracic Vertebral Body, sponsored by St. Louis University. Terminated at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-03-24.

Sponsored by St. Louis University · Not applicable, Interventional, and Treatment

Why this study was terminated
Recruitment and follow up concerns during Covid-19 pandemic
Phase
Not applicable
Study type
Interventional
Enrollment
1
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

Spinal orthoses have been used in the treatment of non-operative thoracic and lumbar fractures with much success. However, there has been increasing questioning as to wether or not the orthotics are necessary to have a good overall outcome. Being fitted for and acquiring braces are associated with great expense and increased hospital stays. The purpose of this study is to determine wether or not braces are required for good outcome post thoracic or lumbar fracture.

Read the detailed description

Several tens of patient's per year come to the Emergency Department with thoracolumbar spine compression and burst fractures that are not indicated for surgical fixation. Currently, these patients are treated non-operatively through brace wear which is either custom made for the patient or is off-the-shelf pending location of the fracture and surgeon preference. All braces are through the currently contracted orthotics company. As they are non stocked in house, waiting for the brace requires the patients to remain on "strict spine precautions" (flat bed rest in a Miami J collar, no pillows behind the head, and logrolls for turning) for anywhere from 24-48 hours. No only is this incredibly uncomfortable for the patient, it is also extending their hospital stay for at least one day and, sometimes, up to three as they wait for the brace and have it adjusted to fit appropriately. The patient's all have to then wait to work with physical therapy and occupational therapy and, finally, have upright spine films taken in the brace. The braces tend to be very uncomfortably and constricting for patient's and significantly inhibit their daily lives. The investigators are proposing that these fractures can be treated without needing bracewear and will have equivalent to superior outcomes than results while wearing the brace.

02

Conditions studied

  • Thoracic Fracture
  • Lumbar Fracture
  • Compression Fracture of Thoracic Vertebral Body
  • Compression Fracture of Lumbar Spine
  • Burst Fracture of Thoracic Vertebra
  • Burst Fracture of Lumbar Vertebra
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Any acute, stable thoracic or lumbar compression or burst fracture appropriate for non-operative care

Exclusion criteria

Exclusion Criteria:

  • neurological deficit, pregnant, incarcerated, non-English speaking, previous spinal surgery, additional lower extremity injury affecting weight bearing, younger than 18 years of age
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
1 participant (actual)

Study arms

  • Active comparator
    Spinal Orthosis (LSO, TLSO, etc)

    Patient's in this arm will be given an orthosis for the treatment of their injury (TLSO for thoracic or upper lumbar injury, LSO for lumbar injury)

    Other: Spinal Orthosis (LSO, TLSO)

  • Experimental
    No Spinal Orthosis

    the patient's in this arm will not be given an orthotic. They will be given a bending restriction and otherwise remain activities as tolerated.

    Other: No orthosis

Interventions

  • OtherSpinal Orthosis (LSO, TLSO)

    spinal orthosis prescribed for specific spinal fracture (TLSO for thoracic or high lumbar fracture, LSO for lumbar fracture)

  • OtherNo orthosis

    no orthotic given for spinal fracture. These patient's will be given a bending restriction

05

What researchers measure

Primary outcomes

  1. Oswestry Disability Index (ODI)

    Primary outcome is the ODI which is a a self-completed questionnaire over ten topics regarding pain, lifting, ability to perform activities of daily living, ability to walk, sit, stand, one's sexual function, social life, sleep quality, and ability to travel. Each category has six different statements from which the patient can choose to best describe their current status. Each question is then scored on a scale from 0-5. Scores are summed and then doubled. The index is from 0-100 with zero being no disability and one hundred being maximally disabled.

    Time frame: 6 month post-injury

Secondary outcomes

  1. Visual analog scale (VAS)

    VAS is a continuous scale represented as a horizontal line with vertical dashes numbered 0-10. Each number is given a pain intensity descriptor that ranges from "no pain" (score of 1) to "worst imaginable pain" (score of 10). The patient is asked to rate the pain they are currently experiencing on that scale from 1-10

    Time frame: Time of injury and at follow up at 2 weeks, 6 weeks, 3 months, 6 months, 1 year, 2 years

  2. SF-12

    Time frame: time of injury and follow up at 2 weeks, 6 weeks, 3 months, 6 months, 1 year, 2 years

  3. PROMIS (Patient-Reported Outcomes Measurement Information System)- physical function

    PROMIS is a U.S. NIH initiative that is an item bank of self-administered questions to measure physical function. This includes functionality of one's upper extremities (dexterity), lower extremities (mobility), neck, back, as well as ability to perform activities of daily living. This assessment measures current function rather than function over a time period. Each question has five response options ranging in value from 1-5. The total raw score for the form is the sum of the values of the response to each question. The raw score (which can range from 10 (worst) to 50 (best) is then compared to a PROMIS specific conversion chart to the appropriate T-score. A T-score of roughly 50 is considered 'average' and 'slightly sicker than the general population'.

    Time frame: time of injury and follow up at 2 weeks, 6 weeks, 3 months, 6 months, 1 year, 2 years

  4. Return to Work Status

    Patient's will be asked if they currently work at time of injury and at each consecutive follow up appointment will be asked if they have returned to work

    Time frame: follow up at 2 weeks, 6 weeks, 3 months, 6 months, 1 year, 2 years

06

Study locations

1 site
  • Saint Louis University Hospital
    Saint Louis, Missouri 63110, United States
07

Registry details

Key details

Study ID
NCT03952182
Lead sponsor
St. Louis University
Responsible party
William Behrens, MD (Resident Physician, St. Louis University) — Principal investigator
First posted
May 16, 2019
Start date
Jan 5, 2020
Primary completion
Mar 15, 2020
Completion
Mar 22, 2022
Last update
Mar 24, 2022

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
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