An observational study in Carotid Atherosclerosis, sponsored by Neuromed IRCCS. Status unknown at 1 site in Italy. Open to participants aged 45 Years to 90 Years. Per ClinicalTrials.gov, last updated 2022-04-11.
Sponsored by Neuromed IRCCS · Observational
The hypothesis of this study is that neural regulations of the atherosclerotic plaque, identified in the murine model of atherosclerosis, could also exist in human pathology. The dysregulation status of the autonomic nervous system is typical of several cardiovascular diseases, but the role it exerts in the modulation of important mechanisms at the basis of the atherosclerotic process progression has not been investigated yet. The main aim of this study will be to investigate, in the atherosclerotic plaque, the alterations of inflammatory and immune processes, the neural modulations and the presence of dysregulations of the autophagic process. The investigators will also associate the potential presence of neural modulations of the plaque to its stability/instability, from a clinical-translational point of view. Finally, the investigators aim at providing a solid basis for the development of novel therapeutic strategies, which could reduce the elevated health and welfare costs for the clinical management of cardiovascular pathologies such as atherosclerosis.
257 studies on the registry are indexed under Carotid Artery Diseases; 58 are open to participants now.
This study's planned enrollment of 50 is below the median of 224 across 112 observational studies indexed under Carotid Artery Diseases.
Browse Carotid Artery Diseases studies →Neuromed IRCCS is the lead sponsor of 79 studies on the registry; 24 are open to participants now.
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Subjects will be selected from patients who will undergo to surgical intervention of carotid trombo-endo-arterectomy at the Department of Vascular Surgery of the IRCCS Neuromed, accordingly to the following inclusion/exclusion criteria. Approximately 50 subjects of both genders will be included in the study.
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Exclusion Criteria:
Patients who undergo surgical intervention of carotid trombo-endo-arterectomy at the Department of Vascular Surgery of the IRCCS Neuromed, with specific inclusion/exclusion criteria
Other: No interventions
No interventions - observational study
Characterization of the neuro-modulation of immune system in atherosclerosis
Immunohistochemistry and immunofluorescence of the autonomic nervous and immune systems in the atherosclerotic plaque, and flow cytometry analysis of circulating immune cells.
Time frame: At enrollment
Characterization of the autophagic process and correlation with neural modulations of the stability/instability plaque
Expression of autophagic markers and immunohistochemical analysis of the atherosclerotic plaque.
Time frame: At enrollment
Plan to share: No
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This study is status unknown, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.
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Neuromed IRCCS