An interventional study of Peri-implantitis debridement and Dental hygiene procedures in Peri-Implantitis, sponsored by University of Washington. Completed at 2 sites in United States. Open to participants aged 25 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-07-05.
Sponsored by University of Washington · Not applicable, Interventional, and Screening
Peri-implantitis is an inflammatory disease that leads to loss of jawbone around dental implants. Recent discoveries have identified increased release of Titanium (Ti) particles around implants as being associated to peri-implantitis. In this ancillary study to the Dental Hygiene and Peri-Implant Tissues Homeostasis trial the objective is to determine potential triggers of increased Ti dissolution from the implant surface and the mechanisms by which Ti dissolution products amplify peri-implant inflammation. Results from this study will determine whether there is a differential response to Ti particles across individuals, which may alter susceptibility to peri-implantitis.
304 studies on the registry are indexed under Peri-Implantitis; 84 are open to participants now.
This study's enrollment of 34 is below the median of 40 across 182 interventional studies indexed under Peri-Implantitis.
Browse Peri-Implantitis studies →University of Washington is the lead sponsor of 1,397 studies on the registry; 225 are open to participants now.
Of its 154 completed or terminated interventional studies of FDA-regulated products, 132 (86%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Titanium curettes
Procedure: Peri-implantitis debridement · Other: Dental hygiene procedures
Implant brush
Procedure: Peri-implantitis debridement · Other: Dental hygiene procedures
Mechanical cleaning of titanium implants, peri-implantitis debridement.
Titanium scalers and nylon brushed used for implant cleaning
Titanium Dissolution
The primary outcome of the clinical trial will be titanium dissolution in periimplant plaque following treatment quantified using inductively coupled mass spectrometry (ICMS)
Time frame: 12 weeks +/- 4 weeks
Expression of pro-inflammatory cytokines in response to titanium
We will determine whether PBMCs from peri-implantitis persons and controls have a differential pro-inflammatory response to titanium particles.
Time frame: baseline
This study is completed, as verified in Jun 2023. You cannot join it, but the record below documents what was studied.
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University of Washington