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CompletedNCT03907345Updated Mar 30, 2023

Generalized Fear Extinction to Untreated Fear Stimuli in Specific Phobias After Exposure

An interventional study of Exposure in Fear of Spiders and Fear of Heights, sponsored by Ruhr University of Bochum. Completed at 1 site in Germany. Open to participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2023-03-30.

Sponsored by Ruhr University of Bochum · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
50
Allocation
Randomized
Ages
18 Years to 40 Years
Sex
All
01

Study summary

This study investigates whether a one-session exposure treatment for spider-related stimuli can lead to a generalization of extinguished fear to height-related stimuli in individuals with comorbid fear of spiders and fear of heights.

Read the detailed description

Exposure therapy has been proven to be effective in the treatment of specific phobias and in a variety of fear evoking situations and stimuli. However, since there is a high prevalence of comorbid fears, therapeutic interventions can get very extensive when each fearful situation and / or stimuli needs to be treated separately and over a repeated number of times. It has recently been shown, that exposure to one fearful stimuli (i.e., a spider), can also lead to a reduction of fear to another, perceptually and conceptually related, but untreated fearful stimulus (i.e., a cockroach) (Preusser, Margraf \& Zlomuzica, 2017). Potentially, this generalization of exposure effects might also be relevant for coexisting fears that do not share conceptually related fearful stimuli (e.g., fear of spiders and fear of heights). The present study aims to investigate whether successful exposure treatment to one fearful stimulus (i.e., a spider) can also lead to a reduction of fear to an untreated fear evoking stimulus (i.e., height).

Participants will be randomly assigned to the treatment or no-treatment condition. The entire experimental procedure will take place in three sessions. The first session incorporates spider and height fear related questionnaires and two Behavioral Approach Tests (BATs): One that involves a spider and one that involves height. These BATs are counterbalanced in each group with half of participants receiving the spider BAT first and the height BAT second, and vice versa. The second session takes place approximately seven days later. The treatment group receives a seven-step in vivo exposure with spiders (duration: 1,5 hours). Twenty-four hours later, session 3 takes place and involves the same measures that were applied in session 1. The treatment and no-treatment group receive an identical set of measures except that the no-treatment group will not be subjected to exposure. The effects of exposure-based anxiety reductions toward spiders (treated fear stimulus) and heights (untreated fear stimulus to assess generalization of treatment outcome) are assessed on the behavioral and subjective level at pretreatment and posttreatment (24 hours after exposure).

02

Conditions studied

  • Fear of Spiders
  • Fear of Heights

Keywords

  • Exposure Therapy
  • Fear of Spiders
  • Fear of Heights
  • Anxiety Disorders
  • Generalization
  • Extinction
  • Specific Phobias
03

In context

Arachnophobia

26 studies on the registry are indexed under Arachnophobia; 2 are open to participants now.

This study's enrollment of 50 is below the median of 60 across 26 interventional studies indexed under Arachnophobia.

Browse Arachnophobia studies →

Lead sponsor

Ruhr University of Bochum is the lead sponsor of 126 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 40 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Comorbid presence of fear of spiders and fear of heights [Potential diagnosis of specific phobias (arachnophobia and acrophobia) assessed by application of the Diagnostic Short-Interview for Mental Disorders (Mini-Dips)].

Exclusion criteria

Exclusion Criteria:

  • Any acute or chronic mental and / or somatic disease
  • Psychological, psychiatric, neurological or pharmacological treatment (Application of the Mini-DIPS to screen for the presence of a psychological condition)
  • Drug or alcohol abuse
  • Pregnancy
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
50 participants (actual)

Study arms

  • Experimental
    Exposure

    Participants of this arm receive one 120-minute session of exposure treatment for spider fear.

    Behavioral: Exposure

  • No intervention
    No Exposure

    Participants of this arm receive no exposure or other adequate treatment.

Interventions

  • BehavioralExposure

    The exposure session comprises a hierarchy of 7 steps, reaching from (1) holding a glass with the spider 30cm in from the body / face, to (7) letting the spider walk on the arm. The exposure session has a duration of 120 minutes. Prior to the exposure, participants receive psychoeducation on anxiety and phobias. A house spider (Tegenaria domestica) is used for the exposure.

06

What researchers measure

Primary outcomes

  1. Behavioral Approach Test (BAT) for Spiders

    Change in the Behavioral Approach Test (BAT) with spiders (treated fear stimulus) \[Time Frame: Pretreatment (approx. 1 week before the treatment), Posttreatment (1 day after treatment), Follow-up (4 weeks between treatment and follow-up)\]. During the Behavioral Approach Test (BAT) the closest distance to a spider as well as subjective fear and heart rate is measured.

    Time frame: Change in BAT scores from pre- to posttreatment (across one week from pretreatment to posttreatment)

  2. Behavioral Approach Test (BAT) for Heights

    Change in the Behavioral Approach Test with heights (untreated fear stimulus) \[Time Frame: Pretreatment (approx. 1 week before the treatment), Posttreatment (1 day after treatment), Follow-up (4 weeks between treatment and follow-up)\]. During the Behavioral Approach Test (BAT) the level of the approached height as well as subjective fear and heart rate is measured.

    Time frame: Change in BAT scores from pre- to posttreatment (across one week from pretreatment to posttreatment)

Secondary outcomes

  1. Fear of Spiders Questionnaire (FSQ)

    Change in the Spider-fear related questionnaires \[Time Frame: Pretreatment (approx. 1 week before the treatment), Posttreatment (1 day after treatment), Follow-up (4 weeks between treatment and follow-up)\]. Self-report questionnaires assessing fear of spiders will be used. The Fear of Spiders Questionnaire (FSQ) will be applied. Scores on this scale range from 0 to 108, with higher scores indicating greater fear of spiders.

    Time frame: Change in FSQ scores from pre- to posttreatment (across one week from pretreatment to posttreatment)

  2. Spider Fear Questionnaire (SPQ)

    Change in the Spider-fear related questionnaires \[Time Frame: Pretreatment (approx. 1 week before the treatment), Posttreatment (1 day after treatment), Follow-up (4 weeks between treatment and follow-up)\]. Self-report questionnaires assessing fear of spiders will be used. The Spider Fear Questionnaire (SPQ) will be applied. Scores on this scale range from 0 to 31, with higher scores indicating greater fear of spiders.

    Time frame: Change in SPQ scores from pre- to posttreatment (across one week from pretreatment to posttreatment)

  3. Spider Beliefs Questionnaire (SBQ)

    Change in the Spider-fear related questionnaires \[Time Frame: Pretreatment (approx. 1 week before the treatment), Posttreatment (1 day after treatment), Follow-up (4 weeks between treatment and follow-up)\]. Self-report questionnaires assessing fear of spiders will be used. The Spider Beliefs Questionnaire (SBQ) will be applied. Scores on this scale range from 0 to 100, with higher scores indicating greater fear of spiders.

    Time frame: Change in SBQ scores from pre- to posttreatment (across one week from pretreatment to posttreatment)

  4. Acrophobia Questionnaire (AQ)

    Change in the height related questionnaire \[Time Frame: Pretreatment (approx. 1 week before the treatment), Posttreatment (1 day after treatment), Follow-up (4 weeks between treatment and follow-up)\]. Self-report questionnaires assessing fear of heights will be used. The German version of the anxiety subscale of the Acrophobia Questionnaire (AQ) will be used. Scores on these scales range from 0 to 120, with higher scores indicating greater fear of heights.

    Time frame: Change in AQ scores from pre- to posttreatment (across one week from pretreatment to posttreatment)

Other outcomes

  1. Fear and Disgust Rating

    Self-developed, computerized fear and disgust ratings of 30 pictures of various animals (i.e., different mammals, insects, rodents, reptiles, birds). Participants have to rate their level of fear and disgust for each animal separately on a scale from 0 to 100. Higher scores indicate greater fear and disgust for each animal.

    Time frame: Change in Fear and Disgust Rating from pre- to posttreatment (across one week from pretreatment to posttreatment)

07

Study locations

1 site
  • Mental Health Research and Treatment Center
    Bochum, 44787, Germany
08

References and documents

Publications

  • Preusser F, Margraf J, Zlomuzica A. Generalization of Extinguished Fear to Untreated Fear Stimuli after Exposure. Neuropsychopharmacology. 2017 Dec;42(13):2545-2552. doi: 10.1038/npp.2017.119. Epub 2017 Jun 7. PubMed 28589965 ↗
  • Margraf, J. & Cwik, J. C. (2017). Mini-DIPS Open Access: Diagnostic Short-Interview for Mental Disorders. [Mini-DIPS Open Access: Diagnostisches Kurzinterview bei psychischen Störungen]. Bochum: Forschungs- und Behandlungszentrum für psychische Gesundheit, Ruhr-Universität. doi:10.13154/rub.102.9

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 30, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03907345
Responsible party
Armin Zlomuzica (Principal Investigator, Ruhr University of Bochum) — Principal investigator
First posted
Apr 8, 2019
Start date
Jun 6, 2019
Primary completion
Oct 7, 2022
Completion
Oct 7, 2022
Last update
Mar 30, 2023

Study contacts

Armin Zlomuzica, PhD
principal investigator · Ruhr-University Bochum

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Mar 2023. You cannot join it, but the record below documents what was studied.

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