An interventional study of [year1] dual-task training with task priority strategy and [year2-3] dual-task training with internal and external focus in Parkinson Disease, sponsored by National Taiwan University Hospital. Terminated at 1 site in Taiwan. Open to participants aged 40 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-02-13.
Sponsored by National Taiwan University Hospital · Not applicable, Interventional, and Treatment
[year1]
[year 2-3]
To investigate the learning effects of walking with internal/external focus on walking automaticity and brain plasticity in dual-task walking training for PD patients with/without freezing of gait.
Postural-suprapostural task is defined as postural control takes place while another concurrent task is being performed, belonging to dual-task paradigms. Effective dual-task training is important to patients with Parkinson disease (PD), because they often lose balance and fall in dual-task conditions. Attentional strategy includes 1) task-priority between postural and suprapostural tasks and 2) internal and external focus for the postural task, which is the critical factor for both dual-task control and motor learning. However, the appropriateness of attentional strategy has not been investigated in dual-task training in patients with PD. Besides, there is lack of neural evidence of brain plasticity for previous studies about dual-task training in patients with PD. With the uses of EEG, EMG and behavioral measures, the purpose of this 3-year research project is to investigate the differences in performance quality and intrinsic neural mechanisms of dual-task training in PD, by adopting task-priority strategy and internal/external strategy during weight-shifting and walking. In the first year, the investigators will characterize task-priority effect (posture-priority vs. supraposture-priority) on dual-task training, with a special focus on modulation of brain plasticity and muscle activity patterns in weight-shifting posture for patients with PD. In the second and third years, the learning effects of walking internal/external focus on walking automaticity and brain plasticity will be investigated in dual-task walking training for PD patients with/without freezing of gait. Besides, the transfer effects of dual-task learning will be also investigated on medication "off" state. The present project is expected to have significant contributions not only to gain a better insight to neural correlates of dual-task training with different attentional strategies under weight-shifting and walking, but to optimize treatment strategy for PD patients with balance or dual-tasking disturbances.
4,487 studies on the registry are indexed under Parkinson Disease; 1,082 are open to participants now.
This study's enrollment of 1 is below the median of 40 across 3,294 interventional studies indexed under Parkinson Disease.
Browse Parkinson Disease studies →National Taiwan University Hospital is the lead sponsor of 2,563 studies on the registry; 569 are open to participants now.
Of its 11 completed or terminated interventional studies of FDA-regulated products, 2 (18%) have results posted.
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[year1]
Inclusion criteria:
For people with Parkinson's disease
age and gender matched healthy subjects as control group
Exclusion criteria:
[year2-3] inclusion criteria:
exclusion criteria:
Behavioral: [year1] dual-task training with task priority strategy
Behavioral: [year1] dual-task training with task priority strategy
Behavioral: [year2-3] dual-task training with internal and external focus
Behavioral: [year2-3] dual-task training with internal and external focus
postural focus: focus mainly on postural performances while dual-tasking suprapostural focus: focus mainly on suprapostural performances while dual-tasking
internal focus: focus mainly on body movements external focus: focus mainly on object in the environment
postural performance
measuring the amount of body weight shifting (unit: kg)
Time frame: about 36 seconds for each trial for a total of 25 minutes
suprapostural performance
measuring the rotation angle of box on the hand (unit: degree)
Time frame: about 36 seconds for each trial for a total of 25 minutes
Walking speed
collecting by using the GAITRite electronic walkway (CIR systems, Inc. ,USA) 24 inches(61cm) wide and 192 inches (488cm, 16ft) long, total 18,432 sensor (unit: m/s)
Time frame: about 10-20 seconds for each trial
Cadence
collecting by using the GAITRite (unit: step/s)
Time frame: about 10-20 seconds for each trial
Gait symmetry
collecting single leg supporting time of right and left leg by using the GAITRite
Time frame: about 10-20 seconds for each trial
electroencephalography (EEG)
to collect the brain activity (unit: uV)
Time frame: about 36 seconds for each trial for a total of 25 minutes
electromyography (EMG)
to collect the muscle activity (unit: mV)
Time frame: about 36 seconds for each trial for a total of 25 minutes
This study is terminated, as verified in Mar 2019. You cannot join it, but the record below documents what was studied.
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National Taiwan University Hospital