An interventional study of High frequency extra thoracic oscillations vest and Intrathoracic oscillatory quake in Chronic Obstructive Pulmonary Disease, sponsored by Cairo University. Completed at 1 site in Egypt. Open to male participants aged 45 Years to 72 Years. Per ClinicalTrials.gov, last updated 2023-08-30.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
Chronic Obstructive Pulmonary Disease (COPD) is the fourth-leading cause of death. It is a progressive illness that requires life-long treatment.Promoting airway clearance (AC) using mucolytics together with airway clearance techniques (ACTs) form the basis for pulmonary therapy in COPD care.Therefore, new airway clearance modalities are required to decrease the detrimental effects of accumulated secretions in COPD.
One of the devices used in AC is the high frequency chest wall oscillation (The Vest). HFCWO involves the use of an inflatable vest/jacket that covers the chest and is attached to an air pulse-generating compressor which rapidly inflates and deflates the vest, producing oscillations to the chest wall of 5-25 Hz.
Another new airway clearance modality is oscillating positive expiratory pressure(Quake) which combines PEP therapy with high frequency oscillations.
The present study aimed to evaluate the effectiveness of the extra thoracic oscillations via high frequency chest wall oscillation vest (HFCWO) versus the intra thoracic oscillations via oscillatory positive expiratory pressure (OPEP) Quake device in COPD Group A: consists of 30 patients will be treated by high frequency chest wall oscillation vest along with their prescribed medical treatment. This program will be performed 4 times per week for 6 successive weeks.
Group B: consists of 30 patients will be treated by vibratory PEP (The Quake) along with their prescribed medical treatment. This program will be performed 4 times per week for 6 successive weeks.
4,253 studies on the registry are indexed under Pulmonary Disease, Chronic Obstructive; 707 are open to participants now.
This study's enrollment of 60 is below the median of 70 across 3,008 interventional studies indexed under Pulmonary Disease, Chronic Obstructive.
Browse Pulmonary Disease, Chronic Obstructive studies →Cairo University is the lead sponsor of 4,909 studies on the registry; 1,445 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
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All patients were diagnosed by chest physician based on the modified criteria defined in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines 2017.
Exclusion Criteria:
high frequency chest wall oscillation vest performed 4 times per week for 6 successive weeks for 30 patients
Device: High frequency extra thoracic oscillations vest
Vibratory positive expiratory pressure quake performed 4 times per week for 6 successive weeks for 30 patients
Device: Intrathoracic oscillatory quake
Oscillations applied extra thoracic through vest device aiming for airway clearance
Oscillation introduced intrathoracic through quake device through placing quake in mouth and ordering patient to breathing to move secretions
Pulmonary function test (spirometry)
* it measure ventilatory functions. * Then the patients sat comfortably and upright while putting the nose clip and relax. * The patient was asked to inhale as deeply as possible, hold the breath, and then inserted the mouthpiece carefully into the mouth. * The patient held the mouthpiece tightly between the lips, and kept tongue down. * The patient was asked to exhale for as long as possible and blow for at least 6 seconds.
Time frame: Before and 6 weeks
impulse oscillometry
The patient was in sitting position, Legs kept uncrossed The patient firmly supported his cheeks during measurement. The mouthpiece was at a comfortable height so that the neck is slightly extended and ensure that there is a tight seal between the mouthpiece and lips to prevent air leak. The patient was instructed to perform normal tidal breathing in a relaxed state during the procedure. The recording was performed for at least 30-45 s. During this period, around 120-150 sound impulses were pushed into the lungs from which the mean reactance and resistance values were determined at frequencies from 5 to 20 Hz.
Time frame: before and 6 weeks
This study is completed, as verified in Aug 2023. You cannot join it, but the record below documents what was studied.
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Pulmonary Disease, Chronic Obstructive →