An observational study in Hypertension, Pregnancy-Induced, sponsored by First Affiliated Hospital, Sun Yat-Sen University. Recruiting at 1 site in China. Open to female participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-07-24.
Sponsored by First Affiliated Hospital, Sun Yat-Sen University · Observational
Hypertensive disorder complicating pregnancy is a set of diseases of pregnancy coexisting with elevated blood pressure. The incidence of it is approximately 5-12%. Pregnancy-induced hypertension is a pregnancy-specific disorder, severely impairing both maternal and fetal health, and the major cause of maternal and perinatal mortality rate increased. But so far, the specific etiology is still unclear.
Recently, fibroblast growth factor 23 (FGF23) has emerged as key endocrine regulators of the metabolism of vitamin D and calcium and phosphorus by combining FGFR-α- Klotho receptor complex. Current studies showed that α- Klotho involved the development of gestational hypertension via the production of endothelial nitric oxide, angiogenesis, and the formation of antioxidant enzymes. On the other hand, vitamin D deficiency during pregnancy has an adverse impact on maternal and fetal health, including gestational hypertension. Therefore, the relationship of the expression of FGF23 and the development of gestational hypertension has attracted the attention of relevant scholars.
The aim of this study is to detect the difference of the expression of FGF23 between the hypertensive women and normal pregnant women.
100 pregnant women with hypertensive disorder complicating pregnancy and 200 normal pregnant control women matched for maternal and gestational age were enrolled in the study. All the subjects underwent antepartum screening in the First Affiliated Hospital of Sun Yat-sen University. Blood samples were obtained after overnight fasting at the first, second and third trimester respectively. Serum FGF23 levels were determined by enzyme-linked immunosorbent assay (ELISA) and were correlated with anthropometric, metabolic, and endocrine parameters.
Data were analyzed by SPSS 20.0 database. The results were expressed as mean ± standard deviations or median with interquartile range. Differences between groups were assessed by Student's unpaired t test, Mann-Whitney U test, or Chi-square test as appropriate. Correlation analysis was performed using the Spearman rank correlation method. To identify independent relationships and adjust the effects of covariates, multiple linear regression analyses were performed. P values of \<0.05 were considered significant.
437 studies on the registry are indexed under Pregnancy Complications; 119 are open to participants now.
This study's planned enrollment of 300 is close to the median of 320 across 205 observational studies indexed under Pregnancy Complications.
Browse Pregnancy Complications studies →First Affiliated Hospital, Sun Yat-Sen University is the lead sponsor of 155 studies on the registry; 51 are open to participants now.
Counted across the registry records on this site, refreshed daily.
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Exclusion Criteria:
Those women (subjects) with pregnancy-induced pregnancy.
Those healthy pregnant women
Expression of FGF23
expression of FGF23 in different groups in mmol/l
Time frame: up to 14 weeks
Expression of FGF23
expression of FGF23 in different groups in mmol/l
Time frame: up to 28 weeks
Expression of FGF23
expression of FGF23 in different groups in mmol/l
Time frame: up to 40 weeks
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First Affiliated Hospital, Sun Yat-Sen University