An observational study in Turner Syndrome, Isolated Growth Hormone Deficiency and Cognitive Functions, sponsored by University Hospital, Angers. Completed at 3 sites in France. Open to female participants aged 7 Years to 16 Years. Per ClinicalTrials.gov, last updated 2026-08-18.
Sponsored by University Hospital, Angers · Observational
Turner syndrome (TS) is a rare chromosomal disorder characterized by partial or complete loss of one of the X chromosomes that affects about one in every 2000 female babies born. These young patients described difficulties making friends, understanding others' emotions and intentions, and controlling their own emotions. Difficulties in these domains could led to social withdrawal, to reduced social skills and could have a significant impact on self esteem and mental health as well as on long-term academic and social functioning in affected individuals. The purpose of this project is to identify functional and dysfunctional cognitive and socio-cognitive abilities in these young patients which could account social difficulties described by some of them and their family. To this end, 35 girls with TS and 35 girls with isolated growth hormone deficiency and normal cerebral MRI will be recruited. Subjects will be 7 to 16 years and 11 months of age. Socio-cognitive and cognitive functions will be assessed with neuropsychological and experimental tasks. Questionnaires completed by patient, parents or teacher, will evaluate social and behavioral functioning.
Cross-sectional study (2 groups : Turner syndrome, isolated growth hormone deficiency), not randomized, controlled, associating several specialized centers in endocrine diseases.
The pediatric endocrinologist of the participating centers will contact parents of each patient or voluntary child/adolescent in order to inform them of the study.
The visit of inclusion will take place in the participant center during a routine monitoring visit.
The first visit (V1) will take place immediately after the visit of inclusion in order to avoid a specific displacement for the needs for the study. The second visit (V2) will take place in participant's home. Each visit (V1 and V2) will last half-day. The period between V1 and V2 will be three months maximum.
The visits V1 and V2 will be carried out by neuropsychologists of the Laboratoire de Psychologie des Pays de la Loire (LPPL - EA 4638).
115 studies on the registry are indexed under Turner Syndrome; 33 are open to participants now.
This study's enrollment of 70 is below the median of 125 across 63 observational studies indexed under Turner Syndrome.
Browse Turner Syndrome studies →University Hospital, Angers is the lead sponsor of 464 studies on the registry; 116 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Turner syndrome group :
Isolated GHD group :
All participants :
EXCLUSION CRITERIA :
Turner syndrome group :
Isolated GHD group :
All participants :
* 35 girls with Turner syndrome (except patients with part of a Y chromosome in their karyotype and r(X) cases). * age : 7 years -16 years and 11 months. * Psychological evaluation of cognition, social cognition and affective cognition
Behavioral: psychological evaluation
* 35 girls with isolated Growth Hormone Deficiency (GHD). * age : 7 years -16 years and 11 months. * Psychological evaluation of cognition, social cognition and affective cognition
Behavioral: psychological evaluation
* Neuropsychological and experimental tasks will assess cognitive and socio-cognitive functions. * Questionnaires will assess psychoaffective aspects (depression, anxiety, self-esteem), and social and behavioral functioning.
Wechsler Intelligence Scale for Children (WISC-V)
intelligence scale.
Time frame: 3 months
Cognitive theory of mind first order
First order theory of mind tasks (Baron-Cohen et al., 1985)
Time frame: 3 months
Cognitive theory of mind second order
second-order theory of mind tasks Perner \& Wimmer, 1983)
Time frame: 3 months
Cognitive theory of mind advanced
advanced theory of mind tasks (Happé, 1994)
Time frame: 3 months
Cognitive theory of mind : humor
Humor understanding task
Time frame: 3 months
Affective theory of mind : faux pas
Faux pas recognition test (Baron Cohen et al., 1999)
Time frame: 3 months
Affective theory of mind : first order
First-order affective theory of mind tasks
Time frame: 3 months
Affective theory of mind : second order
Second-order affective theory of mind tasks
Time frame: 3 months
Affective theory of mind : emotional inference
Emotional inference for context test
Time frame: 3 months
Emotional valence recognition : valence
Emotional valence rating from visual scenes
Time frame: 3 months
Facial emotion recogniton
Facial emotion recognition task
Time frame: 3 months
Vocal emotion recognition
Emotional prosody recognition task
Time frame: 3 months
Emotional regulation
Emotion Regulation Questionnaire for Children and Adolescents (ERQ-CA)
Time frame: 3 months
Alexithymia
Questionnaire d'alexithymie chez l'enfant (QAE)
Time frame: 3 months
Empathy
Interpersonal Reactivity Index (IRI)
Time frame: 3 months
Oral Language comprehension abilities 1
Comprehension of Instructions (NEPSY-II, Korkman et al., 2012)
Time frame: 3 months
Oral Language comprehension abilities 2
Verbal comprehension index (from WISC-V)
Time frame: 3 months
Visual and visual-spatial abilities:1
Arrows subtest (NEPSY-II - Korkman et al., 2012),
Time frame: 3 months
Visual and visual-spatial abilities:2
Picture Puzzles subtest (NEPSY-II - Korkman et al., 2012)
Time frame: 3 months
Visual and visual-spatial abilities:3
Benton Facial Recognition Test (Benton et al., 1983)
Time frame: 3 months
Executive abilities-Verbal Working memory 1
Verbal information updating task
Time frame: 3 months
Executive abilities-Visuo-Spatial Working memory 2
Visuo-spatial information updating task
Time frame: 3 months
Executive abilities-Inhibition 1
Stroop test.
Time frame: 3 months
Executive abilities-Inhibition 2
Tapping test
Time frame: 3 months
Executive abilities-Inhibition 3
non-verbal cancellation task
Time frame: 3 months
Executive abilities-Cognitive Flexibility 1
Verbal fluency task (NEPSY-II Korkman et al., 2012)
Time frame: 3 months
Executive abilities-Cognitive Flexibility 2
Modified Wisconsin Card Sorting Test for children
Time frame: 3 months
Executive abilities-Cognitive Flexibility 3
Trail Making Test
Time frame: 3 months
Executive abilities-Higher-order executive functions 1
script generation task
Time frame: 3 months
Executive abilities-Higher-order executive functions 2
Rey Complex Figure Test : Copy
Time frame: 3 months
Executive abilities in daily life
Behavioral Rating Inventory of Executive Functions
Time frame: 3 months
Self Esteem
Rosenberg self-esteem scale (1965).
Time frame: 3 months
Depression inventory
Depression: Children's Depression Inventory (Kovacks \& Beck, 1977).
Time frame: 3 months
Anxiety inventory
Revised Children's Manifest Anxiety Scale (Reynolds \& Richmond, 1999).
Time frame: 3 months
Social desirability
Children's Social Desirability Scale (Crandall et al., 1965)
Time frame: 3 months
social adjustment 1
Conners' Parent Rating Scale-Revised: Short Form (Conners, 1997)
Time frame: 3 months
social adjustment 2
Conners' Teacher Rating Scale-Revised: Short Form (Conners, 1997)
Time frame: 3 months
behavioral adjustment
Child Behavior Checklist (Achenbach, 1991).
Time frame: 3 months
This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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University Hospital, Angers