An observational study in Anemia, Critical Illness and Lung Transplantation, sponsored by Medical University of Vienna. Terminated at 1 site in Austria. Open to participants aged 18 Years to 99 Years. Per ClinicalTrials.gov, last updated 2023-05-17.
Sponsored by Medical University of Vienna · Observational
The main goal of this pilot study is to assess the time course of eicosanoid profiles in intensive care unit (ICU) patients requiring packed red blood cell (PRBC) transfusion. Moreover we will analyze the change of levels of eicosanoids in patient plasma prior and after a PRBC transfusion as well as its correlation with levels of eicosanoids in the transfused PRBCs. These data will then be used to determine the estimated effect size necessary for the planning of future larger studies. We hypothesize that transfusion of PRBCs will modulate the eicosanoid profile in ICU patients.
According to the Protocol filed with the Institutional Review Board of the Medical University of Vienna and patient's informed consent, subsequent sub analyses using samples of this study (e.g., determination of extracellular vesicles in PRBC samples and patient's plasma) will be performed.
1,881 studies on the registry are indexed under Critical Illness; 462 are open to participants now.
This study's enrollment of 23 is below the median of 130 across 867 observational studies indexed under Critical Illness.
Browse Critical Illness studies →Medical University of Vienna is the lead sponsor of 1,076 studies on the registry; 177 are open to participants now.
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Group 1: routine postoperative ICU patients after open aortic surgery Group 2: routine postoperative ICU patients with immunosuppression after lung transplantation Group 3: mixed postoperative ICU patients
Exclusion Criteria:
Diagnostic Test: Analysis of eicosanoid profile prior to and after PRBC transfusion
Diagnostic Test: Analysis of eicosanoid profile prior to and after PRBC transfusion
Diagnostic Test: Analysis of eicosanoid profile prior to and after PRBC transfusion
Using liquid chromatography-mass spectrometry to analyze the eicosanoid profile in patient plasma and aliquoted of the PRBCs prior to and after PRBC transfusion.
Change of plasma eicosanoid concentrations in ICU patients subjected to PRBC Transfusion at any time Point compared to baseline
Time frame: 60 minutes prior to 90 minutes after packed red blood cell transfusion
Changes of plasma eicosanoid profiles after PRBC transfusion compared to prior to PRBC transfusion in ICU patients
Time frame: 60 minutes prior to 90 minutes after packed red blood cell transfusion
Correlation of plasma eicosanoid profiles in the transfused PRBCs and the change of their plasma levels in ICU patients
Time frame: 60 minutes prior to 90 minutes after packed red blood cell transfusion
Plan to share: Undecided
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This study is terminated, as verified in May 2023. You cannot join it, but the record below documents what was studied.
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Medical University of Vienna