An observational study in Patients With Fatty Liver Disease, sponsored by HaEmek Medical Center, Israel. Terminated at 1 site in Israel. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2023-03-06.
Sponsored by HaEmek Medical Center, Israel · Observational
This study investigates the relation between the gastrointestinal tract bacteria and the progression of fatty liver disease .
In the gastrointestinal (GI) tract live wide spectrum of bacteria, in this study we are trying to find if there is a relation between the GI tract bacteria and the development of non alcoholic fatty liver disease, the results of the this study may help us identify the stage of liver disease in noninvasive means and enables us to adopt methods to reduce morbodity.
2,081 studies on the registry are indexed under Liver Diseases; 390 are open to participants now.
This study's enrollment of 62 is below the median of 167 across 681 observational studies indexed under Liver Diseases.
Browse Liver Diseases studies →HaEmek Medical Center, Israel is the lead sponsor of 228 studies on the registry; 12 are open to participants now.
Counted across the registry records on this site, refreshed daily.
60 patients with fatty liver disease
Exclusion Criteria:
20 patients with uncomplicated liver disease, with fibrosis stage 0-1F.
Other: fibroscan and stool sample
20 patients with liver disease, fibrosis stage 2F.
Other: fibroscan and stool sample
20 patients with advanced liver disease, fibrosis stage 3-4F.
Other: fibroscan and stool sample
patients undergo ultrasaound (fibroscan) in order to stage the liver disease.
Also known as: fibroscan is also called shear wave
Transient Elastography Test
Ultrasound Elastography is a non-invasive test which uses the technology of Shear Wave Elastography (SWE) obtained from the right liver lobe for staging liver fibrosis according to Metavir Fibrosis Score . Metavir Fibrosis Score is a system used to assess the extent of inflammation and fibrosis by histopathological evaluation in a liver biopsy. Liver fibrosis assessed by Shear Wave Elastography is well correlated to biopsy using Metavir Score. The outcome of the test will be correlated to Metavir Score system according to the chart below: SWE (kiloPascal) , METAVIR score, Fibrosis Level. Below 5 , F0 , No fibrosis. 5.0-7.1 , F1 , Mild Fibrosis. 7.1-8.7 , F2 , Significant Fibrosis. 8.7-10.4 , F3 , Sever Fibrosis . 10.4-19 , F4 , Cirrhosis.
Time frame: up to 2 hours
Gastrointestinal Microbiome test
The test will be made by a new meta-genomic sequencing technology (Next Generation Sequencing) which gives us unbiased information about all the gastrointestinal bacterial characteristics.
Time frame: up to 1 month
Plan to share: No
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This study is terminated, as verified in Mar 2023. You cannot join it, but the record below documents what was studied.
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HaEmek Medical Center, Israel