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CompletedNCT03744806Updated Nov 16, 2018

Blood-aqueous Barrier Integrity in Eyes Undergoing Intravitreal Bevacizumab Therapy to Treat Neovascular AMD

An observational study in Exudative Age-related Macular Degeneration, sponsored by Medical University of Lublin. Completed. Per ClinicalTrials.gov, last updated 2018-11-16.

Sponsored by Medical University of Lublin · Observational

Study type
Observational
Model
Case-control
Time perspective
Retrospective
Enrollment
48
Sex
All
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Study summary

The aim of this study is to evaluate the effect of repeated intravitreal bevacizumab injections on blood-aqueous barrier permeability in eyes with neovascular age-related macular degeneration (AMD).

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Conditions studied

  • Exudative Age-related Macular Degeneration
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In context

Macular Degeneration

1,474 studies on the registry are indexed under Macular Degeneration; 206 are open to participants now.

This study's enrollment of 48 is below the median of 106 across 421 observational studies indexed under Macular Degeneration.

Browse Macular Degeneration studies →

Lead sponsor

Medical University of Lublin is the lead sponsor of 60 studies on the registry; 10 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Sampling method
Non-probability sample

Study population

primary care clinic

Inclusion criteria

  • active AMD-associated choroidal neovascularization (CNV) confirmed with fluorescein angiography (FA) and optical coherence tomography (OCT)

Exclusion criteria

Exclusion Criteria:

  • history of uveitis, vitreous hemorrhage, neovascular glaucoma, corneal opacities, recent ocular surgery (within 3 months), or prior anti- vascular endothelial growth factor (VEGF) injections
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Study design

Observational model
Case-control
Time perspective
Retrospective
Enrollment
48 participants (actual)
Patient registry
No

Groups and cohorts

  • treated with intravitreal bevacizumab.

    Drug: Bevacizumab Injection

  • control group

Interventions

  • DrugBevacizumab Injection
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What researchers measure

Primary outcomes

  1. Anterior chamber (AC) inflammation evaluated with laser flare photometry.

    All patients were examined before and 1 day and 1 month after each intravitreal bevacizumab injection. Subjects were followed for a period of 4 months in both the study and control groups. The final flare photometry value was automatically calculated by averaging 5 individual measurements. A total of 7 measurements were obtained, but the highest and lowest measurement values were excluded by the flare meter. All statistical analyses were performed using STATISTICA 12 statistical software.

    Time frame: 4 months

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Study locations

No study locations are listed for this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 16, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03744806
Lead sponsor
Medical University of Lublin
Responsible party
Sponsor
First posted
Nov 16, 2018
Start date
Jan 2015
Primary completion
Sep 2015
Completion
Aug 2018
Last update
Nov 16, 2018
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2018. You cannot join it, but the record below documents what was studied.

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