An interventional study of control group and MTA group in Apical Periodontitis and Wound Heal, sponsored by Recep Tayyip Erdogan University Training and Research Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-02-25.
Sponsored by Recep Tayyip Erdogan University Training and Research Hospital · Not applicable, Interventional, and Treatment
A total of 40 periapical lesions from the 33 patient undergoing apical surgery were randomly selected from December 2016-November 2017. Patients were informed about the surgical procedure and signed a consent form. Groups were divided in to 4; as control, MTA (mineral trioxide aggregate), PRF (platelet rich fibrin) and MTA+PRF groups. Apical resection was performed in all groups. No other interventions were made to the control group.
Routine radiographs were taken in the 1st. 3th and 6th months. In the (approximately) 12th month of the procedures computerized tomography scans were taken. Primary healing of the periapical tissues were evaluated and the outcomes were measured. Patients have still been under control for the long term outcomes of the study.
44 apically infected periapical lesions were decided to enroll to the study from December 2016-November 2017. However; a total of 40 periapical lesions undergoing apical surgery were recruited for the planned clinical trial in the end. The study was conducted under randomized controlled protocol. Patients were informed about the surgical procedures and signed a consent form. The anticipated outcomes, possible risks and benefits of the study as well as the alternative treatment options were explained to the patients.
Groups were designed to have 10 patients in each and randomly divided into four as; control, MTA, PRF and MTA+PRF. Apical resection was performed in all groups. No other interventions were made to the control group.
Routine radiographs were taken in the 1st. 3th and 6th months. In the 12th month of the procedures computerized tomography (CT) scans were taken. Primary healing of the periapical tissues were evaluated according to the volumes and the densities of the lesions. Outcomes were measured. Comparison between the initial and the last 3D CT scan volumes were made by medical image processing software (MIMICS, Belgium). Patients have still been under control for the long term outcomes of the study.
256 studies on the registry are indexed under Periapical Periodontitis; 65 are open to participants now.
This study's enrollment of 36 is below the median of 60 across 222 interventional studies indexed under Periapical Periodontitis.
Browse Periapical Periodontitis studies →Recep Tayyip Erdogan University Training and Research Hospital is the lead sponsor of 88 studies on the registry; 19 are open to participants now.
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Exclusion Criteria:
Apical resection group. Only root resection was applied without any other interventions (like prf or mta)
Procedure: control group
Root resection was applied and MTA was inserted through the apical foramen
Procedure: MTA group
Root resection was applied and PRF was placed to the surgically prepared area
Procedure: PRF group
Root resection was applied. MTA was inserted through the apical foramen and PRF was placed to the surgically prepared area
Procedure: MTA + PRF group
a procedure used to prevent or resolves apical periodontitis.
Also known as: root resection
a procedure used to prevent or resolves apical periodontitis.
Also known as: mineral trioxide aggregate
a procedure that is used for wound healing
Also known as: platelet rich fibrin
a procedure used to prevent or resolves apical periodontitis in combination with a procedure that is used for wound healing.
Also known as: mineral trioxide aggregate + mineral trioxide aggregate
Radiographic success - in volume
Evaluation of tomographic outcomes (differences between preoperative and postoperative volume of periapical lesions)
Time frame: 1 year
Radiographic success - in density
Evaluation of tomographic outcomes (differences between preoperative and postoperative density of periapical lesions)
Time frame: 1 year
Plan to share: No — data can be available 6 months after the acceptance of the paper
This study is completed, as verified in Feb 2019. You cannot join it, but the record below documents what was studied.
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Recep Tayyip Erdogan University Training and Research Hospital