An observational study in Heart Failure, sponsored by Shanghai 10th People's Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-01-09.
Sponsored by Shanghai 10th People's Hospital · Observational
The objective of this work is to investigate and then to sequence new biomarkers in the blood of patients with heart failure, and study their diagnostic, risk stratification and prognostic value.
Blood samples (plasma or serum) for heart failure patients presenting dyspnea or edema and with increased NT-proBNP. The objective of this work is to investigate and then to sequence new proteins or microRNAs in the blood of these patients for diagnostic, risk stratification and prognostic purpose.
5,701 studies on the registry are indexed under Heart Failure; 1,220 are open to participants now.
This study's planned enrollment of 3,000 is above the median of 200 across 1,679 observational studies indexed under Heart Failure.
Browse Heart Failure studies →Shanghai 10th People's Hospital is the lead sponsor of 167 studies on the registry; 45 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with heart failure.Patients presenting with shortness of breathor edema and with increased NT-proBNP.
Exclusion Criteria:
Patients with heart failure (HF) who are followed in the hospital or clinic setting, with optimization of medical therapy and blood collection.
Diagnostic Test: Patients with heart failure
Participants will have serial blood collection on medical therapy for heart failure
Number of participants with cardiaovascular death after 5-year follow up
The cardiovascular mortality after 5-year follow up will be assessed to detect prognostic values of circulating biomarkers
Time frame: 5 years
Time to decompensated heart failure (HF) requiring in-patient admission or ER visit or IV diuretic therapy in the outpatient realm
New onset of classic symptoms and signs of destabilized HF, including lower extremity edema, jugular venous distension, bibasilar crackles, orthopnea and paroxysmal nocturnal dyspnea.
Time frame: 5 years
Comparison of new biomarker with NT-ProBNP on diagnostic value in patients with heart failure
Compare the sensitivity and specificity of new biomarker with NT-ProBNP to assess the accuracy of diagnostic value in discriminating heart failure from non-heart failure participants.
Time frame: 1 year
Change From Baseline in left ventricular ejection fraction
Assess the change in left ventricular ejection fraction at the end of 5-year follow up.
Time frame: 5 years
Change From Baseline in left ventricular end-systolic volume
Assess the change in left ventricular end-systolic volume at the end of 5-year follow up.
Time frame: 5 years
Plan to share: Undecided — IPD will be available with reasonable request.
This study is status unknown, as verified in Jan 2020. You cannot join it, but the record below documents what was studied.
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Shanghai 10th People's Hospital