An observational study in Sepsis, Surgery and Acute Kidney Injury, sponsored by Uppsala University. Recruiting at 1 site in Sweden. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-12.
Sponsored by Uppsala University · Observational
Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality. The mechanisms for sepsis-induced AKI are largely unknown. Our hypothesis is that the inflammatory response to an infection cause collateral damage to host tissue and contributes to the development of AKI. In this study we want to investigate the presence of novel inflammatory mediators in patients with sepsis, patients subjected to major surgery (sterile inflammation) and non-inflamed patients and correlate their levels with the risk for AKI.
1,899 studies on the registry are indexed under Sepsis; 462 are open to participants now.
This study's planned enrollment of 100 is below the median of 160 across 931 observational studies indexed under Sepsis.
Browse Sepsis studies →Uppsala University is the lead sponsor of 381 studies on the registry; 84 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients subjected to major surgery or intensive care
Patients admitted to the intensive/post operative care unit
Exclusion Criteria:
Patients admitted to the intensive care unit with sepsis
Patinets subjected to major surgery and then admitted to the intensive care unit
Otherwise healthy patients admitted to the intensive care unit because of intoxication.
Histones
Correlation between levels of histones and degree of acute kidney injury
Time frame: Within 1 month
Other inflammtory mediators
Correlation between levels of other inflammtory mediators and degree of acute kidney injury
Time frame: Within 1 month
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Uppsala University