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RecruitingNCT03297255Updated Sep 29, 2017

Primary Liver Cancer Cohort of South China

An observational study in Primary Liver Cancer, sponsored by Huilian Zhu. Recruiting at 1 site in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2017-09-29.

Sponsored by Huilian Zhu · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
4,000
Ages
18 Years to 80 Years
Sex
All
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Study summary

This longitudinal observational cohort study was designed to investigate factors that influencing the occurrence and long-term survival of patients with primary liver cancer. Basic informations and detailed diagnosis informations (AJCC/TNM stage, MELD score, Child-Pugh score, and BCLC stage) were collected by professional doctors. Clinical outcomes (death, recurrence, and metastasis) will be followed up every two years after therapy.

Read the detailed description

Primary liver cancer (PLC) is highly malignant with high mortality which is particularly popular in China. Many factors are believed to associate with the occurrence and prognosis of liver cancer. This longitudinal observational cohort study was designed to investigate factors that influencing the occurrence and long-term survival of patients with primary liver cancer.

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Conditions studied

  • Primary Liver Cancer

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Keywords

  • Primary Liver Cancer; Cohort Study
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Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients of this study were invited from Sun Yat-sen University Cancer Center as soon as they were diagnosed as primary liver cancer

Inclusion criteria

  • age 18-80 years
  • consistent with primary liver cancer diagnostic criteria
  • first diagnosis (from diagnosis to admission interval of less than a month)
  • did not do any treatment of liver cancer

Exclusion criteria

Exclusion Criteria:

  • refused to participate in this study
  • suffering from more than two kinds of primary tumors
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
4,000 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna
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What researchers measure

Primary outcomes

  1. Time of Death

    The exact death time of each participants will be checked in the government medical records system

    Time frame: Up to 10 years

Secondary outcomes

  1. Time of recurrence

    Time of recurrence will be obtained by telephone interview or medical treatment records

    Time frame: From date of diagnosis until the date of cancer recurrence or date of death from any cause, whichever came first, assessed up to 10 years

  2. Time of metastasis

    Time of metastasis will be obtained by telephone interview or medical treatment records

    Time frame: From date of diagnosis until the date of cancer metastasis or date of death from any cause, whichever came first, assessed up to 10 years

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Study locations

1 of 1 sites recruiting
  • Sun Yat-sen University Cancer Center
    Guangzhou, Guangdong 510000, China
    Recruiting
07

References and documents

Publications

  • Liu ZY, Yishake D, Fang AP, Zhang DM, Liao GC, Tan XY, Zhang YJ, Zhu HL. Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study. Nutr Metab (Lond). 2020 Mar 30;17:25. doi: 10.1186/s12986-020-00445-z. eCollection 2020. PubMed 32256673 ↗
  • Liu ZY, Tan XY, Li QJ, Liao GC, Fang AP, Zhang DM, Chen PY, Wang XY, Luo Y, Long JA, Zhong RH, Zhu HL. Trimethylamine N-oxide, a gut microbiota-dependent metabolite of choline, is positively associated with the risk of primary liver cancer: a case-control study. Nutr Metab (Lond). 2018 Nov 20;15:81. doi: 10.1186/s12986-018-0319-2. eCollection 2018. PubMed 30479648 ↗
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Registry details

Key details

Study ID
NCT03297255
Lead sponsor
Huilian Zhu
Responsible party
Huilian Zhu (Professor, Sun Yat-sen University) — Sponsor-investigator
First posted
Sep 29, 2017
Start date
Jan 1, 2013
Primary completion
Dec 2025 (estimated)
Completion
Dec 2025 (estimated)
Last update
Sep 29, 2017

Study contacts

Zhu Huilian, Professor
Contact
zhuhl@mail.sysu.edu.cn
+86 20 87331811
Fang Aiping
Contact
fangaip@mail.sysu.edu.cn
020-87335875 ext. 504
Zhu Huilian, Professor
study chair · Sun Yat-sen University
View the source record on ClinicalTrials.gov ↗

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