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CompletedNCT03708653Updated Apr 23, 2019

Single Nucleotide Polymorphisms (SNPs) Associated With Postherpetic Neuralgia

An observational study in Postherpetic Neuralgia, sponsored by Second Affiliated Hospital, Zhejiang University, School of Medicine. Completed at 1 site in China. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2019-04-23.

Sponsored by Second Affiliated Hospital, Zhejiang University, School of Medicine · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
181
Ages
50 Years and older
Sex
All
01

Study summary

Postherpetic neuralgia (PHN) is a common condition and affecting 5 to 30% of the herpes zoster patients. In some cases, the pain remained refractory after first and second line treatment for herpes zoster. This suggests that there may be genetic variants that make some patients susceptible to PHN. Using saliva samples from herpes zoster patients the investigators are going to analyze the relationship between single nucleotide polymorphisms (SNPs) in genes that are known to be involved in pain and PHN.

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Conditions studied

  • Postherpetic Neuralgia
03

In context

Neuralgia, Postherpetic

200 studies on the registry are indexed under Neuralgia, Postherpetic; 31 are open to participants now.

This study's enrollment of 181 is above the median of 147 across 30 observational studies indexed under Neuralgia, Postherpetic.

Browse Neuralgia, Postherpetic studies →

Lead sponsor

Second Affiliated Hospital, Zhejiang University, School of Medicine is the lead sponsor of 97 studies on the registry; 65 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
50 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Herpes zoster patients in a large university hospital

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Age more than 50 years
  • Clinically defined herpes zoster patients

Exclusion criteria

Exclusion Criteria:

  • Patients not able to provide informed consent
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
181 participants (actual)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • PHN(+)

    Patients who have persistent pain more than three months after the onset of herpes zoster.

  • PHN(-)

    Patients whose pain disappear within three months.

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What researchers measure

Primary outcomes

  1. correlation between pain SNPs and PHN

    Time frame: At Enrollment

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Study locations

1 site
  • The second affiliated hospital of Zhejiang University
    Hangzhou, Zhejiang 310000, China
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Apr 2018 to primary completion in Feb 2019, 10 months.

How these figures are worked out, and which studies are left out of them.

Registered
Sep 5, 2018
First posted
Oct 17, 2018
StartActual
Apr 1, 2018
Primary completionActual
Feb 13, 2019
CompletionActual
Feb 13, 2019
Last update
Apr 23, 2019
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 23, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT03708653
Lead sponsor
Second Affiliated Hospital, Zhejiang University, School of Medicine
Responsible party
Sponsor
First posted
Oct 17, 2018
Start date
Apr 1, 2018
Primary completion
Feb 13, 2019
Completion
Feb 13, 2019
Last update
Apr 23, 2019

Study contacts

Min Yan, Doctor
study director · Zhejiang University

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2018. You cannot join it, but the record below documents what was studied.

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Discussion

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Other studies in this condition

Neuralgia, Postherpetic →

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Second Affiliated Hospital, Zhejiang University, School of Medicine

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