An observational study in Bleeding, Angiogenesis and Peri-Implantitis, sponsored by Universitaire Ziekenhuizen KU Leuven. Completed at 1 site in Belgium. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-03-31.
Sponsored by Universitaire Ziekenhuizen KU Leuven · Observational
Angiogenesis is inherently associated to bone formation and healing. During implant osseointegration, a successive and successful angiogenic processes has to occur to promote bone formation. In 1969, Branemark et al. demonstrated that direct contact between bone and titanium implant surface was possible, defining osseointegration as "the direct, structural, and functional contact between live bone and the surface of a functionally loaded implant". Consequently, the need of an empirical measurement appeared. With the introduction of resonance frequency analysis (RFA), it is now possible to measure the degree of implant stability at any time during the course of implant treatment and loading. In this way, changes in implant stability can be monitored over the time and it is likely possible to find implants at risk of failure before they become loose. The rationale of this study is to analyse how important a good vascularization is for the future bone formation around dental implants.
304 studies on the registry are indexed under Peri-Implantitis; 84 are open to participants now.
This study's enrollment of 102 is above the median of 80 across 116 observational studies indexed under Peri-Implantitis.
Browse Peri-Implantitis studies →Universitaire Ziekenhuizen KU Leuven is the lead sponsor of 928 studies on the registry; 261 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Patients who come to the Unit of Periodontology (UZ Leuven, St. Rafaël), in need of implant rehabilitation, will be evaluated for initial study eligibility during a screening visit. Patients shall be advised of the need to attend follow-up visits: 3 months after implant placement (at abutment placement visit) and 1 year, the latter to analyse the early bone remodelling.
Exclusion Criteria:
Local exclusion criteria:
Correlation between bleeding during implant placement and marginal bone loss
Peri-implant bone loss after 1 year from the implant placement
Time frame: 1 year
Correlation between bleeding during implant placement and implant stability quotient (ISQ) values
Correlation between bleeding during implant placement and implant stability quotient (ISQ) values
Time frame: 3 months
This study is completed, as verified in Oct 2018. You cannot join it, but the record below documents what was studied.
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Universitaire Ziekenhuizen KU Leuven