Study of Anti-Mesothelin Car NK Cells in Epithelial Ovarian Cancer

1. Mesothelin-positive patients with stage II-IV epithelial ovarian cancer.（Mesothelin expression ≥50% of tumor cells）（Patients with recurrence are not excluded）
2. Male or female, 18 to 70 years old (including 18 and 70 years old)
3. The excepted survival ≥ 6 months,Karnofsky activity function status score ≥ 60 points
4. there are measurable lesions according to the RECIST 1.1 standard.
5. Bone marrow function (blood routine) satisfies: the number of neutrophils > 1×109/L platelet > 7.5×109/L; hemoglobin > 90 g/L; total bilirubin \< 2.0 mg/dL; creatinine \< 1.5 times the upper limit; albumin \< 2 g/L; ALT or AST \< 5 times the upper limit; creatinine clearance rateby Cockcroft-Gault formula\< 40 mL/min
6. Coagulation parameters: INR ≤ 1.5, PTT \< 1.2 times the upper limt
7. Patients did not receive any chemotherapy, radiotherapy, immunotherapy (such as immunosuppressive drugs PD-1, PDL-1) or other anticancer treatment 2-4 weeks before admission, and the treatment-related toxicity reaction ≤1 level prior to enrollment（except low toxicity lose hair for example）
8. Venous channel is unobstructed, which can meet the needs of intravenous drip
9. HIV test was negative; HBV and HCV were negative
10. Voluntary informed consent is given, agree to follow the trial treatment and visit plan

Exclusion Criteria:

1. Patients with hypertension (> 160/95 mmHg) are uncontrollable; coronary heart disease and angina pectoris are unstable (Canadian Cardiovascular Association Level II and above), or recurrent within 6 months
2. Patients suffer from concurrent or central nervous system diseases
3. Patients with severe autoimmune diseases or immunodeficiency diseases
4. Patient's lung function has the following abnormalities: FEV (forced expiratory volume), \< 30%; DLCO (diffusing capacity of lung for carbon monoxide) \< 30%; oxygen saturation \< 90%
5. Patients treated with other immune cellular products (DC, CIK, T, NK, and Car T products with CD19 or other targets)
6. Patients with Severe liver and kidney dysfunction
7. Patients with Severe bacterial and viral infections
8. Patients are pregnant or nursing
9. Patients used corticosteroids within 4 weeks prior to enrollment(except patients with inhaled hormone)
10. Patients participated in other clinical trials within 30 days.
11. Patients had other conditions that were not appropriate for the group determined by the researchers.