CClinicalTrials.gg
CompletedNCT03678610Updated May 7, 2019

Handling Medium for ICSI With Ionomycin and Latrunculin A

An interventional study of Doing ICSI I a medium supplemented with Ionomycin and Latrunculin A in Infertility, sponsored by Ibn Sina Hospital. Completed at 3 sites in Egypt. Open to female participants aged 18 Years to 42 Years. Per ClinicalTrials.gov, last updated 2019-05-07.

Sponsored by Ibn Sina Hospital · Not applicable, Interventional, and Other

Phase
Not applicable
Study type
Interventional
Enrollment
700
Allocation
Randomized
Ages
18 Years to 42 Years
Sex
Female
01

Study summary

Using Latrunculin A and Ionomycin would improve the outcome of ICSI if the handling medium during the ICSI procedure has them.

02

Conditions studied

  • Infertility

Browse trials for

03

In context

Infertility

2,506 studies on the registry are indexed under Infertility; 407 are open to participants now.

This study's enrollment of 700 is above the median of 120 across 1,698 interventional studies indexed under Infertility.

Browse Infertility studies →

Lead sponsor

Ibn Sina Hospital is the lead sponsor of 28 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 42 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Inclusion criteria

  • indication for ICSI

Exclusion criteria

Exclusion Criteria:

-

05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Care provider, Investigator)
Enrollment
700 participants (actual)

Study arms

  • Experimental
    ICSI medium supplemented with Ionomycin and Latrunculin A

    Other: Doing ICSI I a medium supplemented with Ionomycin and Latrunculin A

  • No intervention
    ICSI medium as it is

Interventions

  • OtherDoing ICSI I a medium supplemented with Ionomycin and Latrunculin A

    Ionomycin and Latrunculin A would activate oocyte during ICSI along with cytoskeleton stabilization for a favourable outcomes

06

What researchers measure

Primary outcomes

  1. Fertilization rate

    Time frame: 6 days of culture

Secondary outcomes

  1. Rates of Blastocyst formation and quality

    Number of formed blastocysts and blastocysts with good-quality per fertilized oocytes

    Time frame: 6 days of culture

  2. embryo utilization rate

    Time frame: 6 days of culture

  3. clinical pregnancy rate

    Time frame: three months

  4. ongoing pregnancy rate

    Time frame: 12 weeks

07

Study locations

3 sites
  • Banon Assiut
    Assiut, Egypt
  • Qena Fertility Center
    Qena, 123456, Egypt
  • IbnSina IVF Center
    Sohag, Egypt
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 7, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03678610
Lead sponsor
Ibn Sina Hospital
Collaborators
Banoon IVF Center, Qena Fertility Center
Responsible party
Muhammad Fawzy (IVF Lab Director, Ibn Sina Hospital) — Principal investigator
First posted
Sep 19, 2018
Start date
Sep 25, 2018
Primary completion
May 1, 2019
Completion
May 1, 2019
Last update
May 7, 2019

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2019. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion