An observational study in Rhythm Nodal, Metabolism and Nutrition Disorder and Metabolism Disorder, Lipid, sponsored by Shandong Provincial Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-05-11.
Sponsored by Shandong Provincial Hospital · Observational
The circadian regulation in mammals have been known for a long time. A special group of clock genes, organized in feedback loops, are responsible for the circadian regulation in both the SCN and peripheral organs. The central clock is mainly entrained by the light-dark cycle, while the peripheral ones in organs such as liver and intestine, are more influenced by the feeding-fasting cycles. The coordination of central and peripheral clocks is thought to be essential in the maintenance of physiological homeostasis.This study aim to investigate the association between biological rhythm and metabolism.
997 studies on the registry are indexed under Metabolic Diseases; 234 are open to participants now.
This study's planned enrollment of 200 is above the median of 176 across 300 observational studies indexed under Metabolic Diseases.
Browse Metabolic Diseases studies →Shandong Provincial Hospital is the lead sponsor of 58 studies on the registry; 23 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adults aged of 18 to 30 years old.
Exclusion Criteria:
male with BMI\<28
male with BMI≥28
female with BMI\<28
female with BMI≥28
circadian rhythms of serum lipid levels （the change of serum lipid levels within 24 hours）
Time frame: Measured at baseline, and every 10 years during the 40-year follow-up period
circadian rhythms of gonadal hormone and gonadotropin（the change of gonadal hormone and gonadotropin within 24 hours）
Time frame: Measured at baseline, and every 10 years during the 40-year follow-up period
circadian rhythms of serum total bile acids（the change of serum total bile acids within 24 hours）
Time frame: Measured at baseline, and every 10 years during the 40-year follow-up period
change in urine metabolite
Time frame: Measured at baseline, and every 10 years during the 40-year follow-up period
change in intestinal flora
Time frame: Measured at baseline, and every 10 years during the 40-year follow-up period
change in sperm quality
Time frame: Measured at baseline, and every 10 years during the 40-year follow-up period
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Shandong Provincial Hospital