An interventional study of Blood test in Pre-Eclampsia and Obesity; Endocrine, sponsored by Diyarbakir Women's and Children's Diseases Hospital. Completed at 1 site in Turkey. Open to female participants aged 15 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-01-08.
Sponsored by Diyarbakir Women's and Children's Diseases Hospital · Not applicable, Interventional, and Prevention
The complement C1q tumor necrosis factor-associated protein-9 (CTRP-9), which is responsible for regulating cardiovascular and metabolic functions, increases vascular relaxation by pathway dependent on AMPK / endothelial nitric oxide synthesis (eNOS). The aim of this study was to investigate CTRP-9 levels in pregnant women with preeclampsia.
The most important reason for the development of preeclampsia is the problem of trophoblastinvasion and consequent formation and development of placenta is not healthy
Cytokines are regulatory molecules that have effects on cell functions.Cytokines are molecules that also regulate endothelial functions. Placenta formation and widespread endothelial damage are under the influence of cytokines.
Therefore, there may be important links between impairment or imbalance in cytokine release and function and the formation of preeclampsia.Nitric oxide (NO) is a biologic enzyme that is synthesized by nitric oxide synthase (NOS) from the amino acid of L-arginine and exists in all mammals.
e(NOS) is the three isoforms of NO. It is known that NO is a major vasodilator of pregnancy, inhibiting platelet and leukocyte aggregation.There was a decrease in NO levels in preeclamptic patients.
The CqP / TNF Binding Protein (CTRP) family consists of 15 members, and is synthesized in many organs outside the body of fat.CTRP9 is predominantly excreted in fat tissue, and levels in circulation are reduced in patients with diabetes and obesity.Many studies have shown that CTRP9 exerts beneficial effects on metabolic and cardiovascular homeostasis.
CTRP9 increases vascular relaxation in the AMPK / endothelial nitric oxide synthase (eNOS) dependent pathway. CTRP9 has also been reported to reduce inflammatory responses in endothelial cells via the AMPK-dependent pathway.
Vasorelaxation due to CTRP9 is endothelium-dependent and NO-mediated. CTRP9, directly acting on smooth muscle, is indirectly or indirectly associated with NO production in the vascular endothelial layer by stimulating vasorelaxial molecular production by endothelial cells.
328 studies on the registry are indexed under Eclampsia; 48 are open to participants now.
This study's enrollment of 120 is close to the median of 120 across 169 interventional studies indexed under Eclampsia.
Browse Eclampsia studies →Diyarbakir Women's and Children's Diseases Hospital is the lead sponsor of 3 studies on the registry; none are open to participants now.
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Exclusion Criteria:
CTRP 9 level will be assessed by 40 obese preeclamptic gestational ELISA methods that meet the latest ACOG criteria.
Diagnostic Test: Blood test
CTRP 9 level will be assessed by 40 non-obese preeclamptic gestational ELISA methods that meet the latest ACOG criteria.
Diagnostic Test: Blood test
CTRP 9 level will be assessed by 40 normal gestational ELISA methods
Diagnostic Test: Blood test
For serum analysis, approximately 2 cc antecubital vein venous blood serum will be taken from each patient to be studied for CTRP9 Level analysis. Adult blood will be centrifuged at 4000 rpm for 10 minutes to separate greenhouses. The obtained serum samples will be stored at -80 ° C until analysis.
CTRP 9 level in preeclamptic pregnancies
Blood samples were taken from patients with preeclampsia. The diagnosis was made when the arterial blood pressure was above 140/90 mm / Hg within 6 hours and was accompanied by proteinuria (\> 300 milligrams in a sample) with high blood pressure and number of patients with proteinuria (ACOG criteria)
Time frame: 3 months
Plan to share: Undecided
This study is completed, as verified in Jan 2019. You cannot join it, but the record below documents what was studied.
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Diyarbakir Women's and Children's Diseases Hospital