An interventional study of Acetaminophen in Postoperative Pain and Gynecologic Disease, sponsored by Seoul National University Hospital. Completed at 1 site in Korea, Republic of. Open to female participants aged 19 Years to 80 Years. Per ClinicalTrials.gov, last updated 2021-01-08.
Sponsored by Seoul National University Hospital · Not applicable, Interventional, and Treatment
This study aimed to evaluate the additive effect of acetaminophen on postoperative pain control in patients receiving nefopam and fentanyl-based patient-controlled analgesia.
Participants undergoing laparoscopic hysterectomy will be randomly assigned to treatment group or control group. After end of surgery, acetaminophen or normal saline (placebo) will be administered intravenously depending on the group assigned.
154 studies on the registry are indexed under Genital Diseases, Female; 32 are open to participants now.
This study's enrollment of 84 is close to the median of 80 across 111 interventional studies indexed under Genital Diseases, Female.
Browse Genital Diseases, Female studies →Seoul National University Hospital is the lead sponsor of 1,860 studies on the registry; 275 are open to participants now.
Of its 12 completed or terminated interventional studies of FDA-regulated products, 2 (17%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patients in this group will receive 1 gram of acetaminophen intravenously after the end of surgery.
Drug: Acetaminophen
Patients in this group will receive 100 ml of normal saline intravenously after the end of surgery.
Acetaminophen will be intravenously administrated to treatment group after the end of surgery.
Also known as: treatment
Total volume of administered analgesics during postoperative 24 hours
morphine equivalent dose of patient-controlled analgesics administered during first 24 hours after end of surgery
Time frame: 24 hours
Pain score
11-point numeric rating scale ranging from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")
Time frame: 24 hours
Patient satisfaction score
11-point numeric rating scale ranging from '0' representing one extreme (e.g. "extremely dissatisfied") to '10' representing the other extreme (e.g. "extremely satisfied")
Time frame: 24 hours
Postoperative nausea and vomiting
4-scales scoring (none; mild; moderate; severe)
Time frame: 24 hours
Opioid-related adverse effect
Incidence of respiratory, gastrointestinal, and central nervous system complications
Time frame: 24 hours
Use of alternative analgesics
Additional administration of other analgesics
Time frame: 24 hours
Length of stay
Hospital length of stay
Time frame: From date of hospital admission until the date of discharge, an average of 1 week
This study is completed, as verified in Jan 2021. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Seoul National University Hospital