An interventional study of pH Effect on blastocyst formation in Infertility, sponsored by Ibn Sina Hospital. Completed at 3 sites in Egypt. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2019-07-16.
Sponsored by Ibn Sina Hospital · Not applicable, Interventional, and Other
Any drift in extracellular pH (pHe) from the intercellular pH (pHi) could alter the mechanism regulating transporters and exchangers through the plasma membrane. This could lead to difficulty in restoring the physiological level of pHi. The critical stages that lack robust mechanism of regulating the pHi are the denuded oocyte, early stage of fertilization or a thawed embryo. This, in turn, could lead to a significant effect of the perturbations on embryo development. Convincing evidence regarding the optimal pHe for culturing human embryo is, so far, scanty and mostly anecdotal. The embryo has been reported to have a compensatory mechanism to grow at pHe between 7.0-7.4. Others have recommended that embryo need a sequential pH to viably grow suggesting that the post-genomic activation stage needs a slightly alkaline range of pH. However, whether this holds true remains to be examined.
2,506 studies on the registry are indexed under Infertility; 407 are open to participants now.
This study's enrollment of 1,312 is above the median of 120 across 1,698 interventional studies indexed under Infertility.
Browse Infertility studies →Ibn Sina Hospital is the lead sponsor of 28 studies on the registry; none are open to participants now.
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Exclusion Criteria:
A split embryo at day 3 to continue culture at a pHe of 7.23±0.02 or to be cultured at a pH of 7.35±0.02 and monitor the effect on blastocyst development.
Other: pH Effect on blastocyst formation
Embryo culture from day 0 to 5 or 6 at 7.23
to investigate which pH is suitable for each stage of embryo development
Ongoing Pregnancy rate
women with continued pregnancy at week 12 of gestation
Time frame: 12 weeks
rate of usable blastocysts
number of blastocysts suitable for transfer on day 5 or 6
Time frame: 6 days of culture
Blastocyst formation rate
number of formed blastocyst per Fertilized oocyte
Time frame: 6 days of culture
Clinical pregnancy rate
number of women with ultrasound detection of sacs with heartbeat per stimulated cycle
Time frame: 3 months
Implantation rate
number of sacs with a heartbeat
Time frame: 7 weeks
Plan to share: No
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This study is completed, as verified in Jul 2019. You cannot join it, but the record below documents what was studied.
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Ibn Sina Hospital