An interventional study of Assessment at Low Altitude (470m above sea level) and Exposure to High Altitude (2500m above sea level) in Pulmonary Hypertension, sponsored by University of Zurich. Completed at 1 site in Switzerland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-01-07.
Sponsored by University of Zurich · Not applicable, Interventional, and Prevention
Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude (2500m above sea level) on pulmonary artery pressure and right heart function (Echo) under exercise.
Low altitude baseline measurements will be performed in Zurich (460m asl) including Echocardiography, Right heart catheterization, six-minute walk test (6MWT), pulmonary function test, clinical assessment and blood gas Analysis.
Randomly assigned to the order of testing, the participants will be tested in Low Altitude (Zurich, 470m) and at High Altitude (2500m).
Several times within the exposure, the pulmonary artery pressure and the right heart function will be assessed by echo under exercise.
1,105 studies on the registry are indexed under Hypertension, Pulmonary; 234 are open to participants now.
This study's enrollment of 28 is below the median of 35 across 649 interventional studies indexed under Hypertension, Pulmonary.
Browse Hypertension, Pulmonary studies →University of Zurich is the lead sponsor of 1,030 studies on the registry; 130 are open to participants now.
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Exclusion Criteria:
The participants will be tested in Zurich (Low altitude: 470m above sea level) and consecutively at High Altitude(Säntis; 2500m above sea Level)
Other: Assessment at Low Altitude (470m above sea level) · Other: Exposure to High Altitude (2500m above sea level)
The participants will be tested at High Altitude (Säntis; 2500m above sea level) and consecutively in Zurich (Low altitude; 470m above sea level).
Other: Assessment at Low Altitude (470m above sea level) · Other: Exposure to High Altitude (2500m above sea level)
Assessment at Low Altitude (in Zurich; 470m above sea level) in order to compare this data with High altitude exposure
Exposure to High Altitude (Säntis; 2500m above sea level) for approximately 5 hours
Echocardiographic Assessment at High Altitude (2500m) during exercise
Pulmonary artery pressure will be measured by echo (TTE) under exercise.
Time frame: 1 day at altitude
Echocardiographic right heart assessment at High Altitude (2500m) during exercise
The right heart function (fac, D-Shaping, etc.) will be assessed by echocardiography (TTE) under exercise
Time frame: 1 day at altitude
This study is completed, as verified in Jan 2020. You cannot join it, but the record below documents what was studied.
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University of Zurich