An interventional study of Metacognitive therapy and Intolerance of uncertainty therapy in Generalized Anxiety Disorder, sponsored by Karolinska Institutet. Completed at 1 site in Sweden. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2025-01-30.
Sponsored by Karolinska Institutet · Not applicable, Interventional, and Treatment
The feasibilty and preliminary comparative effectiveness of two methods of cognitive-behavioral therapy - metacognitive therapy and intolerance of uncertainty therapy - for primary care patients with generalized anxiety disorder is investigated in a pilot study using a randomized controlled design. Purpose of the study is to examine the feasibility of a full-scale randomized controlled trial. Research questions primarily concern recruitment, measurement, and adherence.
146 studies on the registry are indexed under Generalized Anxiety Disorder; 86 are open to participants now.
This study's enrollment of 64 is below the median of 100 across 120 interventional studies indexed under Generalized Anxiety Disorder.
Browse Generalized Anxiety Disorder studies →Karolinska Institutet is the lead sponsor of 1,146 studies on the registry; 275 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Behavioral: Metacognitive therapy
Behavioral: Intolerance of uncertainty therapy
Metacognitive therapy is a form av cognitive-behavioral therapy which aims to change cognitions about worry in patients with generalized anxiety disorder.
Intolerance of uncertainty therapy is a form av cognitive-behavioral therapy which aims to reduce cognitive and behavioral avoidance of uncertain situations or cognitions which lead to worry in patients with generalized anxiety disorder.
Penn State Worry Questionnaire - Measure of Symptom Change
Penn State Worry Questionnaire, a self-reported symptom measure of worry. Scale ranges: 16-80 scores on a scale; higher values represent a worse outcome.
Time frame: Change from baseline symptoms at 12 weeks
| Milestone | Metacognitive Therapy | Intolerance of Uncertainty Therapy |
|---|---|---|
| Started | 31 | 33 |
| Completed | 25 | 32 |
| Not completed | 6 | 1 |
Penn State Worry Questionnaire, a self-reported symptom measure of worry. Scale ranges: 16-80 scores on a scale; higher values represent a worse outcome.
| score on a scale | Metacognitive Therapy | Intolerance of Uncertainty Therapy |
|---|---|---|
| Penn State Worry Questionnaire - Measure of Symptom Change | 42.1 ± 7.5 | 55.8 ± 7.5 |
Collected over Not assessed.. Non-serious events are listed at a 5% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Metacognitive Therapy | — | — | — |
| Intolerance of Uncertainty Therapy | — | — | — |
| Age, Continuous(years) | Metacognitive Therapy | Intolerance of Uncertainty Therapy | Total |
|---|---|---|---|
| Mean | 35.7 ± 10.8 | 37.1 ± 11.6 | 36.4 ± 11.1 |
| Sex: Female, Male(Participants) | Metacognitive Therapy | Intolerance of Uncertainty Therapy | Total |
|---|---|---|---|
| Female | 25 | 27 | 52 |
| Male | 6 | 6 | 12 |
| Race and Ethnicity Not Collected(Participants) | Metacognitive Therapy | Intolerance of Uncertainty Therapy | Total |
|---|---|---|---|
| Count of participants | — | — | 0 |
| Region of Enrollment(participants) | Metacognitive Therapy | Intolerance of Uncertainty Therapy | Total |
|---|---|---|---|
| Sweden | 31 | 33 | 64 |
Documents are hosted by the registry — open the source record to download them.
Plan to share: No
This study is completed, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Generalized Anxiety Disorder →