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CompletedNCT03618914Updated Aug 22, 2018

Anemia and Inflammation

An observational study in Iron Deficiency Anemia and Inflammation, sponsored by Swiss Federal Institute of Technology. Completed at 1 site in Morocco. Open to female participants aged 18 Years to 49 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-08-22.

Sponsored by Swiss Federal Institute of Technology · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
50
Ages
18 Years to 49 Years
Sex
Female
01

Study summary

During inflammation hepcidin concentrations are increased, leading to a decrease in iron absorption. In iron deficiency anemia hepcidin is suppressed due to the activation of erythropoiesis. Whether inflammation or anemia has the stronger effect on hepcidin is uncertain.

02

Conditions studied

03

In context

Anemia

1,733 studies on the registry are indexed under Anemia; 246 are open to participants now.

This study's enrollment of 50 is below the median of 200 across 326 observational studies indexed under Anemia.

Browse Anemia studies →

Lead sponsor

Swiss Federal Institute of Technology is the lead sponsor of 152 studies on the registry; 10 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 49 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Young women with or without iron-deficiency anemia

Inclusion criteria

  • BMI \<27.5kg/m2
  • body weight \<70kg
  • either non-anemic (Hb>12.5g/dl) or anemic (Hb between 8-12 g/dl and ferritin \<15ng/ml)

Exclusion criteria

Exclusion Criteria:

  • pregnant or lactating
  • chronic disease
  • smoking
  • inflammation defined as CRP\<5mg/L; AGP\<1g/L
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
50 participants (actual)
Patient registry
No
Biospecimen retention
Samples without dna

Groups and cohorts

  • Non-anemic women

    Biological: Dultavax and Vaxigrip

  • anemic women

    anemia due to iron deficiency

    Biological: Dultavax and Vaxigrip

Interventions

  • BiologicalDultavax and Vaxigrip

    All the women got an influenza/DTP vaccine in order to induce acute inflammation

06

What researchers measure

Primary outcomes

  1. Fractional and total iron absorption

    Time frame: 14 days after the second baseline test meal administration

  2. Fractional and total iron absorption

    Time frame: 14 days after the test meal administered 24 hours after vaccination

Secondary outcomes

  1. Serum hepcidin

    Time frame: up to 36 hours

  2. Serum Interleukin 6

    inflammation

    Time frame: up to 36 hours

  3. Serum ferritin

    Iron status

    Time frame: up to 36 hours

  4. Serum transferrin

    Iron status

    Time frame: up to 36 hours

  5. Serum CRP

    inflammation

    Time frame: up to 36 hours

  6. Serum AGP

    inflammation

    Time frame: up to 36 hours

07

Study locations

1 site
  • Ibn Tofail University-CNESTEN
    Rabat, Morocco
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 22, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03618914
Lead sponsor
Swiss Federal Institute of Technology
Collaborators
Ibn Tofail University-CNESTEN
Responsible party
Prof. Michael B. Zimmermann (Prof. Dr. med., Swiss Federal Institute of Technology) — Principal investigator
First posted
Aug 7, 2018
Start date
Sep 15, 2017
Primary completion
Mar 29, 2018
Completion
Jun 30, 2018
Last update
Aug 22, 2018

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2018. You cannot join it, but the record below documents what was studied.

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