An interventional study of Gas perturbation in Healthy, sponsored by Swiss Federal Institute of Technology. Not yet recruiting. Open to participants aged 18 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-14.
Sponsored by Swiss Federal Institute of Technology · Not applicable, Interventional, and Basic science
In this study, the effects of blood gas perturbations on neuromuscular function of the diaphragm and lower limbs at rest and during exercise will be investigated.
Swiss Federal Institute of Technology is the lead sponsor of 154 studies on the registry; 10 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Each participant will be tested on 4 different days, on each day with a different inspiratory gas mixture applied for 2h.
Other: Gas perturbation
Participants will be breathing a gas mixture of either room air, or hypoxia, or hypercapnia, or a combination of both during 2h. This is followed by an all-out breathing exercise test against a small resistance, while still being in the respective gas condition.
Diaphragm contractility
Diaphragm contractility measured before/during/following the gas exposures and the volitional respiratory muscle exercises using transdiaphragmatic and mouth pressure responses.
Time frame: Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec
Quadriceps contractility
Quadriceps contractility will be assess before, during and following the gas exposures and respiratory muscle contractions
Time frame: Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec.
No study locations are listed for this record.
Start is estimated for Aug 2026; primary completion for Dec 2029, 40 months later.
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This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Swiss Federal Institute of Technology →